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Müllerian-inhibiting substance function during mammalian sexual development
To investigate the role of Müllerian-inhibiting substance (MIS) in mammalian sexual development, we generated MIS-deficient mice. Although MIS-deficient males had testes that were fully descended andExpand
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Structure and axon outgrowth inhibitor binding of the Nogo‐66 receptor and related proteins
The myelin‐derived proteins Nogo, MAG and OMgp limit axonal regeneration after injury of the spinal cord and brain. These cell‐surface proteins signal through multi‐subunit neuronal receptors thatExpand
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Shedding of Kidney Injury Molecule-1, a Putative Adhesion Protein Involved in Renal Regeneration*
KIM-1 (kidney injury molecule-1) is a type I transmembrane glycoprotein expressed on dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or ischemic injury.Expand
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Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.
Müllerian-inhibiting substance (MIS) is a member of the transforming growth factor-beta (TGF-beta) gene family. MIS expression in males causes the regression of the Müllerian ducts, an essentialExpand
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Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells.
The ontogeny of expression of anti-Müllerian hormone (AMH) was examined by immunohistochemistry in 135 human gonadal tissue specimens of various developmental age, ranging from 6 weeks of fetalExpand
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Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells
We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. TheExpand
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Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor
Anti–Müllerian hormone (AMH) and its receptor are involved in the regression of Müllerian ducts in male fetuses. We have now cloned and mapped the human AMH receptor gene and provide genetic proofExpand
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Developmental regulation of GDNF response and receptor expression in the enteric nervous system.
The development of the enteric nervous system is dependent upon the actions of glial cell line-derived neurotrophic factor (GDNF) on neural crest-derived precursor cells in the embryonic gut. GDNFExpand
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The Persistent Müllerian Duct Syndrome: An Update Based Upon a Personal Experience of 157 Cases
Male sex differentiation is driven by 2 hormones, testosterone and anti-müllerian hormone (AMH), responsible for the regression of müllerian ducts in male fetuses. Mutations inactivating AMH or itsExpand
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Anti-müllerian hormone and testosterone serum levels are inversely during normal and precocious pubertal development.
Anti-Müllerian hormone (AMH), also called Müllerian inhibiting substance or factor, is produced by Sertoli cells from fetal life until puberty. In the present study, AMH, testosterone (T), LH, andExpand
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