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Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.
TLDR
The results of this study are consistent with preclinical findings indicating that the pharmacokinetics of doxorubicin are drastically altered using Doxil and follow a pattern dictated by the liposome carrier.
Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast
TLDR
In first-line therapy for MBC, PLD provides comparable efficacy to doxorubicin, with significantly reduced cardiotoxicity, myelosuppression, vomiting and alopecia.
Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
TLDR
It is shown that lympho-depleting chemotherapy followed by transfer of short-term cultured TIL can mediate tumor regression in 50% of metastatic melanoma with manageable toxicity.
Diabetes mellitus and breast cancer.
Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families.
TLDR
The high rate of germ-line BRCA1/BRCA2 mutations in Ashkenazi women and families with ovarian cancer is coupled with penetrance that is lower than previously estimated.
MR-guided focused ultrasound surgery (MRgFUS) for the palliation of pain in patients with bone metastases--preliminary clinical experience.
TLDR
MRgFUS may provide a safe and effective noninvasive alternative for the palliation of pain, caused by bone metastases, in patients for whom other treatments are either not effective or not feasible.
Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2
TLDR
It is determined that risks of breast and ovarian cancer for BRCA1 and BRCa2 mutation carriers ascertained from the general population are as high as for mutation carrier ascertained through personal or family history of cancer.
Pain Palliation in Patients with Bone Metastases Using MR-Guided Focused Ultrasound Surgery: A Multicenter Study
TLDR
The results suggest that MRgFUS has the ability to provide an accurate, effective, and safe noninvasive palliative treatment for patients with bone metastases.
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers
TLDR
RAD51-135C is a clinically significant modifier of BRCA2 penetrance, specifically in raising breast cancer risk at younger ages, and RAD51 status did not affect ovarian cancer risk.
Adiponectin, ghrelin, and leptin in cancer cachexia in breast and colon cancer patients
TLDR
The hormone ghrelin and the adipocytokines leptin and adiponectin participate in body weight regulation and it is hypothesized that responses of these hormones may be attenuated in cancer cachexia.
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