• Publications
  • Influence
EM reconstruction algorithms for emission and transmission tomography.
  • K. Lange, R. Carson
  • Physics, Medicine
  • Journal of computer assisted tomography
  • 1 April 1984
Two proposed likelihood models for emission and transmission image reconstruction accurately incorporate the Poisson nature of photon counting noise and a number of other relevant physical features.Expand
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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
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Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain
The authors developed and applied two new linearized reference tissue models for parametric images of binding potential (BP) and relative delivery (R1) for [11C]DASB positron emission tomographyExpand
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Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.
To assess dynamic changes in brain function throughout the sleep-wake cycle, CBF was measured with H2(15)O and PET in 37 normal male volunteers: (i) while awake prior to sleep onset; (ii) duringExpand
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Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
  • A. Breier, T. Su, +8 authors D. Pickar
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 March 1997
A major line of evidence that supports the hypothesis of dopamine overactivity in schizophrenia is the psychomimetic potential of agents such as amphetamine that stimulate dopamine outflow. A novelExpand
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Altered patterns of cerebral activity during speech and language production in developmental stuttering. An H2(15)O positron emission tomography study.
To assess dynamic brain function in adults who had stuttered since childhood, regional cerebral blood flow (rCBF) was measured with H2O and PET during a series of speech and language tasks designedExpand
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Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional Imaging
  • Y. Wu, R. Carson
  • Mathematics, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 December 2002
The Simplified Reference Tissue Model (SRTM) produces functional images of receptor binding parameters using an input function derived from a reference region and assuming a model with one tissueExpand
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Dissociation of object and spatial visual processing pathways in human extrastriate cortex.
The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in healthy young men. Regional cerebral bloodExpand
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Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis
In an attempt to improve neuroreceptor distribution volume (V) estimates, the authors evaluated three alternative linear methods to Logan graphical analysis (GA): GA using total least squares (TLS),Expand
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