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Neurotensin is a proinflammatory neuropeptide in colonic inflammation.
TLDR
It is concluded that neurotensin plays a key role in the pathogenesis of C. difficile-induced colonic inflammation and mast cell activation and substance P is inhibited by the substance P (neurokinin-1) receptor antagonist CP-96,345, indicating that colonic mast activation in response to neurotens in involves release of substance P.
Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels.
TLDR
Evaluation of purified subfractions of the crude PC concentrate identified a specific bioactive fraction that may participate in triggering the improved jejunal ischemic tolerance.
Autoimmune mechanisms as the basis for human peripartum cardiomyopathy
TLDR
Findings for the first time suggest that such abnormalities may in concert lead to the initiation and perpetuation of an autoimmune process, which leads to cardiac failure and disease.
Evidence for a neurotensin receptor in rat serosal mast cells
TLDR
Results indicate that a specific neurotensin receptor is present on the rat mast cell, suggesting a role in neuro-immune-endocrine interactions.
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