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Vascular endothelial growth factor in eye disease
TLDR
The roles played by VEGF in the pathogenesis of retinopathy of prematurity, diabetic Retinopathy and age-related macular degeneration are described and the potential disadvantages of inhibiting VEGf will be discussed, as will the rationales for targeting other V EGF-related modulators of angiogenesis. Expand
Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity
TLDR
It is indicated that increased arginase activity in diabetes contributes to vascular endothelial dysfunction by decreasing l-arginine availability to NO synthase. Expand
Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives
TLDR
The cellular and molecular alterations that characterize experimental models of diabetes are considered in relation to the influence of high glucose‐mediated oxidative stress on VEGF expression and on the mechanisms of V EGF's actions under hyperglycemic induction. Expand
Therapeutic use of citrulline in cardiovascular disease.
TLDR
Substantial intestinal and hepatic metabolism of L-arginine to ornithine and urea by arginase makes oral delivery very ineffective, and supplemental L-citrulline has promise as a therapeutic adjunct in disease states associated with L- arginine deficiencies. Expand
Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase
TLDR
Data indicate that early diabetes causes breakdown of the BRB by a mechanism involving the action of reactive nitrogen species in promoting expression of VEGF and uPAR. Expand
Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.
TLDR
Partial deletion of either ROCK isoform, but to a greater extent ROCK1, attenuates diabetes-induced vascular endothelial dysfunction by preventing increased arginase activity and expression and reduction in NO production in type 1 diabetes. Expand
Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions.
TLDR
Clinical benefits with PRA not explained by LDL reductions may be the result of an independent action of PRA on eNOS activation, but SIM is much less effective. Expand
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite.
TLDR
The potential use of CBD as a novel topical therapy for the treatment of glaucoma is suggested and the hypothesis that glutamate causes apoptosis of retinal neurons via the excessive formation of peroxynitrite is tested. Expand
Diabetes-induced vascular dysfunction involves arginase I.
TLDR
In diabetic WT and AI(+/-)AII (-/-) mice, aortic arginase activity and AI expression were significantly increased compared with control mice, but neither parameter was altered in AI( +/-) aorta, which indicates a major involvement of AI in diabetes-induced vascular dysfunction. Expand
Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress.
TLDR
Cellular and molecular alterations seen in diabetic models are considered in the context of high glucose-mediated oxidative stress effects on VEGF expression and action and potential therapeutic strategies for preventing V EGF overexpression or blocking its pathological actions in the diabetic retina are considered. Expand
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