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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin action. In aExpand
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Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Summary Dietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly dependentExpand
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Microbiota-induced obesity requires farnesoid X receptor
Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signallingExpand
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Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
Background Obesity is associated with accumulation of macrophages in white adipose tissue (WAT), which contribute to the development of insulin resistance. Germ-free (GF) mice have reduced adiposityExpand
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Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism
Abstract.  Caesar R, Fåk F, Bäckhed F (Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg,Expand
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Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism1[S]
The gut microbiota influences many aspects of host metabolism. We have previously shown that the presence of a gut microbiota remodels lipid composition. Here we investigated how interaction betweenExpand
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Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet
We evaluated the effects of partly substituting lard with marine n-3 fatty acids (FA) on body composition and weight, adipose tissue distribution and gene expression in five adipose depots of maleExpand
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Gut microbiota of obese subjects with Prader-Willi syndrome is linked to metabolic health
Objective The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. Patients with Prader-Willi syndrome (PWS) are obese but partly protected against insulinExpand
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Aberrant intestinal microbiota in individuals with prediabetes
Aims/hypothesisIndividuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota,Expand
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Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe−/− Mice
Objective— To investigate the effect of gut microbiota and diet on atherogenesis. Approach and Results— Here, we investigated the interaction between the gut microbiota and diet on atherosclerosis byExpand
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