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Recent Developments of Cascade Reactions Involving ω‑Transaminases
Enzymatic cascade reactions experience tremendous attention by cutting short conventional step-by-step synthesis in a highly efficient and elegant fashion. Focusing on ω-transaminases, this reviewExpand
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Biocatalytic synthesis of enantiopure building blocks for pharmaceuticals.
Biocatalytic transformations have emerged as a viable alternative to other asymmetric chemical methods due to the intrinsic high stereoselectivity of the enzymes and the mild reaction conditions.Expand
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Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts
This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primaryExpand
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Regio- and stereoselective monoamination of diketones without protecting groups.
) out of six showed perfect regioselectivity forthe differentiation between the two keto groups. Hence, theamination occurred exclusively at the sterically less demand-ing w-1 ketone moiety, leadingExpand
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Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases
  • Justyna Kulig, R. C. Simon, +8 authors Dörte Rother
  • Chemistry
  • 16 July 2012
Although biotransformations implementing alcohol dehydrogenases (ADHs) are widespread, enzymes which catalyse the reduction and oxidation of sterically demanding substrates, especially 2-hydroxyExpand
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Chemoenzymatic Synthesis of (Protected) Psymberic Acid
Two alternative approaches to the side-chain of psymberin (1), psymberic acid (5), have been developed starting from either racemic or enantiopure acetal 6. A five-step chemoenzymatic route providedExpand
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TTC-based screening assay for ω-transaminases: a rapid method to detect reduction of 2-hydroxy ketones.
A rapid TTC-based screening assay for ω-transaminases was developed to determine the conversion of substrates with a 2-hydroxy ketone motif. Oxidation of the compounds in the presence ofExpand
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Chemoenzymatic synthesis of all four diastereomers of 2,6-disubstituted piperidines through stereoselective monoamination of 1,5-diketones.
The regioselectivity of various enantiocomplementary ω-transaminases was evaluated for the stereoselective monoamination of designated 1,5-diketones; excellent conversions, enantio- andExpand
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