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Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-d-aspartic acid antagonism
Various compounds that have been identified in the literature as binding to the [3H]phencyclidine receptor site and as producing behavioral effects similar to phencyclidine (phencyclidine-like)…
Pharmacology of LY201409, a Potent Benzamide Anticonvulsant
The compound did not effectively antagonize seizures induced by a variety of chemical convulsants in rats, but did block pentylenetetrazol‐induced seizures in mice, and displayed potent anticonvulsant activity.
Pharmacological Properties of Recanescine, A New Sedative Alkaloid from Rauwolfia canescens Linn
- I. Slater, R. C. Rathbun, F. G. Henderson, N. Neuss
- Chemistry, MedicineProceedings of the Society for Experimental…
- 1 February 1955
Summary A new alkaloid isolated from Rauwolfia canescens, recanescine, appears to lack the methoxyl group in the C-ll position of reserpine. Preliminary evidence indicates that this compound retains…
Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol.
- D. Robertson, J. Krushinski, E. Beedle, J. Leander, D. Wong, R. C. Rathbun
- Chemistry, MedicineJournal of medicinal chemistry
- 1 September 1986
This series of imidazole anticonvulsants was highly selective; while many compounds displayed potent antielectroshock activity, little or not activity was observed against pentylenetetrazole-induced clonic seizures or in the horizontal screen test for ataxia.
Role of 5‐hydroxytryptaminergic and adrenergic mechanism in antagonism of reserpine‐induced hypothermia in mice
- I. Slater, R. C. Rathbun, R. Kattau
- MedicineThe Journal of pharmacy and pharmacology
- 1 September 1979
The role of biogenic amine uptake in the antagonism of reserpineinduced hypothermia in mice was examined directly and the Duncan multiple range test was used to determine statistical significance of differences among the groups.
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
- D. Wong, R. C. Rathbun, F. Bymaster, W. B. Lacefield
- Chemistry, MedicineLife sciences
- 5 September 1983
The differential effects of LY81067 on the enhancements of 3H-GABA and3H-flunitrazepam binding in several brain regions suggest extensive multiplicity of GABA/benzodiazepine/picrotoxin/anioin receptor complexes.
Pharmacological Effects of Enantiomers of 4‐Amino‐N‐(α‐methylbenzyl)Benzamide, a Chemically Novel Anticonvulsant
- J. Leander, D. Robertson, C. R. Clark, R. Lawson, R. C. Rathbun
- Chemistry, MedicineEpilepsia
- 1 February 1988
LY 188546 is a chemically novel anticonvulsant with a promising pharmacological profile and was the least toxic in terms of neurological impairment and protective indexes.
Effects of Mu- and kappa-opioid receptor agonists on urinary output in mice
The results suggest that kappa agonist activity increases urinary output in mice just as reported for rats, and suggest that in mice morphine has some kappa ligand activity, whereas fentanyl does not.
Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation
It is suggested that although these compounds are effective in antagonizing the central effects of cholinergic agents, they are different in this regard from atropine and other tertiary amines that have been reported to cause hallucinations in patients.
NEUROENDOCRINE AND BEHAVIORAL STUDIES WITH FLUOXETINE, AN INHIBITOR OF SEROTONIN UPTAKE IN BRAIN
Fluoxetine antagonized behavioral and hyperthermic effects of p-chloroamphetamine by blocking its uptake into serotonin neurons, and the effect was enhanced by L-5HTP.