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The structure and specificity of endothelin receptors: their importance in physiology and medicine.
In addition to involvement in vascular endothelium-smooth muscle communication, the secretion of and receptors for, endothelins are widely distributed. Two cloned receptor subtypes areExpand
Blood lipid alterations in infants receiving intravenous fat-free alimentation.
A study has been made of blood plasma lipids in five infants, ages 2 to 6 weeks, who were receiving intravenous alimentation. The solution administered contained glucose, fibrin hydrolysate,Expand
Endothelin receptor heterogeneity; structure activity, autoradiographic and functional studies.
Radioligand binding studies were used to define the binding constants for inhibition of [125I]endothelin-1 binding by endothelin-1 (ET-1), endothelin-3 (ET-3) and a synthetic analogue of ET-1,Expand
Effects of calcium entry blockers on contractions evoked by endothelin‐1, [Ala3,11]endothelin‐1 and [Ala1,15]endothelin‐1 in rat isolated aorta
1 The aim of the present study was to examine the contractile responses evoked by the recently characterized vasoactive peptide endothelin‐1 (ET‐1) and by two of its structural analogues,Expand
Characterization of the [125I]‐neurokinin A binding site in the circular muscle of human colon
Neurokinin A (NKA) is a potent contractile agonist of human colon circular muscle. These responses are mediated predominantly through tachykinin NK2 receptors. In the present study, the NK2 receptorExpand
Specificity of action of Ca++ entry blockers. A comparison of their actions in rat arteries and in human coronary arteries.
Among the large number of compounds which inhibit the contraction evoked by calcium in depolarized smooth muscle, calcium entry blockers are those that specifically block calcium entry during muscleExpand
ACTIONS OF PROSTAGLANDIN F2α AND NORADRENALINE ON CALCIUM EXCHANGE AND CONTRACTION IN RAT MESENTERIC ARTERIES AND THEIR SENSITIVITY TO CALCIUM ENTRY BLOCKERS
1 The actions of prostaglandin F2α (PGF2α) and noradrenaline on contraction and 45Ca exchange have been studied in rat mesenteric arteries. 2 PGF2α and noradrenaline contracted rat isolatedExpand
Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro
1 The effects of histamine have been studied on human isolated coronary artery preparations taken from hearts ranging in age from 9 to 73 years. 2 Histamine in large concentrations (100 μM)Expand
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