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Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer
- Gillian Smith, F. Carey, C. Wolf
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 July 2002
The heterogeneous pattern of tumor mutations in this patient cohort suggests that multiple alternative genetic pathways to colorectal cancer exist and that the widely accepted genetic model of cancer development is not representative of the majority of coloreCTal tumors.
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
In vivo CYP1A2 activity is lower in colorectal cancer patients than in controls, and the genotype had no effect on phenotype (based on the caffeine metabolite ratio), but this remains to be confirmed in a larger study.
Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks.
Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer
Fruit and vegetable consumption were both found to protect against colorectal cancer, while overall meat and red meat consumption were found to increase risk.
Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes.
- J. Bacon, G. Williamson, R. C. Garner, G. Lappin, S. Langouët, Y. Bao
- Biology, ChemistryCarcinogenesis
- 1 December 2003
It is indicated that dietary isothiocyanates and flavonoids modulate phase I and phase II enzyme expression, hence increasing the rate of detoxification of the dietary carcinogen PhIP in human HepG2 cells but do not affect the rates of PhIP-DNA adduct repair.
Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4-…
This study demonstrates the use of AMS in a human phase I study in which the administered radioactive dose was at least 1000-fold lower than that used for conventional radioactive studies.
Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry.
It is demonstrated that after oral administration, tamoxifen forms adducts in human uterine DNA but at low numbers relative to those previously reported in women after long-term tamoxIFen treatment where levels, when detected, ranged from 15000 to 130000 adducted nucleotides.
A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extracts.
Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530.
It is tentatively suggested that the derivative that is toxic to S. typhimurium TA 1530 and the one that reacts with nucleic acids are identical and may be related to the hepatocarcinogenicity of aflatoxin B 1.
Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.
The ability of 51 compounds to induce "unscheduled DNA synthesis" in HeLa cells has been tested in the presence or absence of a rat liver mixed-function oxidase preparation and the use of this assay in a tier scheme for the short-term testing of potential chemical carcinogens is discussed.