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Synaptic vesicle tethering and the CaV2.2 distal C-terminal
Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or “tether” (Stanley, 1993). Recent studies haveExpand
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α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity*♦
Background: α-Synuclein is known to undergo exchange between membrane and cytosolic compartments. Results: α-Synuclein interacts with GTP-bound Rab3a on synaptic vesicles, and its dissociation isExpand
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The Calcium Channel C-Terminal and Synaptic Vesicle Tethering: Analysis by Immuno-Nanogold Localization
At chemical synapses the incoming action potential triggers the influx of Ca2+ through voltage-sensitive calcium channels (CaVs, typically CaV2.1 and 2.2) and the ions binds to sensors associatedExpand
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Cryoloading: introducing large molecules into live synaptosomes
Neurons communicate with their target cells primarily by the release of chemical transmitters from presynaptic nerve terminals. The study of CNS presynaptic nerve terminals, isolated as synaptosomesExpand
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Molecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal
Neurotransmitter is released from presynaptic nerve terminals at fast-transmitting synapses by the action potential-gating of voltage dependent calcium channels (CaV), primarily of the CaV2.1 andExpand
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A MPCDM-enabled Product Concept Design via User Involvement Approach
TLDR
This article reports how designers manipulate a collaborative and reliable process, which is more directly in contact with users and is different from the traditional design approach for interpreting and satisfying users’ specific needs. Expand
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Diabetic Footwear: Materials Choices and Design
The incidence and prevalence rates of diabetes worldwide are increasing and foot complications are rising parallel. There is however lack of adequate knowledge about the role of appropriate footwearExpand
Determination of Comfort and Performance Properties of Upper Materials for Diabetic Footwear Construction
This work investigates comfort and performance properties of selected shoe upper materials manufactured in Nigeria for their suitability for diabetic footwear construction. The research was carriedExpand
8 Regulation of-Synuclein Membrane Binding and Its Implications
1.1 Parkinson’s disease and Lewy bodies Parkinson’s disease (PD) is the most prevalent neurodegenerative disease that affects motor control, although dementia, depression, and other psychiatricExpand