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C-type inactivation controls recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes.
1. A fast inactivating transient K+ current (FK1) cloned from ferret ventricle and expressed in Xenopus oocytes was studied using the two-electrode voltage clamp technique. Removal of theExpand
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A Novel β Subunit Increases Rate of Inactivation of Specific Voltage-gated Potassium Channel α Subunits (*)
Voltage-gated potassium channel β subunits are cytoplasmic proteins that co-purify with the pore-forming α subunits. One of these subunits, Kvβ1 from rat brain, was previously demonstrated toExpand
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Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit (Kv beta 3) cloned from ferret ventricle.
In mammals, voltage-gated K+ channels can be made of complexes containing alpha-subunits similar to the Shaker K+ channel and smaller cytoplasmic beta-subunits. Recent studies have suggested thatExpand
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Molecular mechanisms of K+ channel blockade: 4-aminopyridine interaction with a cloned cardiac transient K+ (Kv1.4) channel.
We studied the blocking effects of 4-aminopyridine (4-AP) on a Kv1.4 K+ channel. A permanently charged 4-AP derivative only produced block when applied intracellularly. 4-AP block accumulated fromExpand
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Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes.
1. Using the two-microelectrode, 'cut open' oocyte, and 'torn off' macropatch voltage clamp techniques, we studied the blocking effects of 4-aminopyridine (4-AP) on two cloned K+ channels expressedExpand
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The Beta Subunit, Kvβ1.2, Acts as a Rapid Open Channel Blocker of NH2-Terminal Deleted Kv1.4 α-Subunits
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of α-subunits belonging to the Kv1 family of potassium channels. One of these subunits, Kvs1.2,Expand
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The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminal deleted Kv1.4 alpha-subunits.
A recently discovered class of ancillary subunits has been shown to modify the inactivation properties of alpha-subunits belonging to the Kv1 family of potassium channels. One of these subunits, KvExpand
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AERODYNAMIC FORCES ON MAGLEV VEHICLES
The results of four separate tasks are documented: 1) minimization of front-end drag; 2) effect of fineness ratio (ratio of length to diameter) on drag; 3) design of aerosurfaces for controlExpand
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