R. Bush

Publications106
h-index35
Citations5,045
Highly Influential Citations224
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Nrl is required for rod photoreceptor development
The protein neural retina leucine zipper (Nrl) is a basic motif–leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. It acts synergistically with Crx to… Expand
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Retinopathy induced in mice by targeted disruption of the rhodopsin gene
Retinitis pigmentosa (RP) represents the most common mendelian degenerative retinopathy of man, involving death of rod photoreceptors, cone cell degeneration, retinal vessel attenuation and… Expand
  • 502
  • 17
P23H rhodopsin transgenic rat: correlation of retinal function with histopathology.
PURPOSE To correlate retinal functional changes with structural changes in P23H rhodopsin transgenic rats as a model of autosomal dominant retinitis pigmentosa. METHODS P23H heterozygote (lines 1… Expand
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  • 17
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Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants.
Neurotrophic factors are agents with a promising ability to retard progression of neurodegenerative diseases and are effective in slowing photoreceptor degeneration in animal models of retinitis… Expand
  • 542
  • 15
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RanBP2 Modulates Cox11 and Hexokinase I Activities and Haploinsufficiency of RanBP2 Causes Deficits in Glucose Metabolism
The Ran-binding protein 2 (RanBP2) is a large multimodular and pleiotropic protein. Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have… Expand
  • 76
  • 10
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Inner retinal contributions to the primate photopic fast flicker electroretinogram.
  • R. Bush, P. Sieving
  • Chemistry, Physics
  • Journal of the Optical Society of America. A…
  • 1 March 1996
The primate electroretinogram (ERG) recorded at the cornea in response to fast flickering light is thought to reflect primarily the cone photoreceptor potential. We investigated the origin of the… Expand
  • 159
  • 9
A proximal retinal component in the primate photopic ERG a-wave.
  • R. Bush, P. Sieving
  • Biology, Medicine
  • Investigative ophthalmology & visual science
  • 1 February 1994
PURPOSE The monkey photopic ERG was studied during administration of glutamate analogs to determine whether the photopic a-wave derives exclusively from photoreceptors. METHODS Monkey photopic ERGs… Expand
  • 253
  • 8
  • PDF
Human melanoma-associated retinopathy (MAR) antibodies alter the retinal ON-response of the monkey ERG in vivo.
PURPOSE Melanoma-associated retinopathy (MAR) is a paraneoplastic condition that causes visual symptoms of night-blindness and photopsias. The electroretinogram (ERG) of MAR patients is… Expand
  • 94
  • 8
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Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor
Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of… Expand
  • 86
  • 7
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RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis.
PURPOSE To create and evaluate a mouse model of human X-linked juvenile retinoschisis (XLRS) and then investigate whether supplementing with the retinoschisin protein by gene delivery can reverse the… Expand
  • 158
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