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Gastric Enterochromaffin-Like Cell Hyperplasia and Neoplasia in the Rat: An Indirect Effect of the Histamine H2-Receptor Antagonist, BL-6341
Oral administration of BL-6341 hydrochloride, a long-acting histamine H2-receptor antagonist, to rats for 2 years at doses of 10, 55 or 300 mg/kg/day resulted in several changes in the fundicExpand
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BMS-189453, a novel retinoid receptor antagonist, is a potent testicular toxin.
BMS-189453 is a synthetic retinoid that acts as an antagonist at retinoic acid receptors alpha, beta, and gamma. In Sprague Dawley rats at daily oral doses of 15, 60, or 240 mg/kg for 1 month,Expand
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Single-dose and multiple-dose intravenous toxicity studies of BMY-25282 in rats.
Single-dose and multiple-dose (daily X 5 and weekly X 5) intravenous toxicity studies in rats were conducted to determine the possible acute and delayed toxicity of BMY-25282Expand
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The toxicologic evaluation of marcellomycin--an antineoplastic anthracycline antibiotic.
Dose-related toxicologic effects of marcellomycin, an antineoplastic anthracycline antibiotic, were observed in single-dose studies in mice iv (43.05-67.65 mg/m2) and dogs iv (41.0-90.2 mg/m2), andExpand
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Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus.
Three analogs of thymidine, D4T [2',3'-didehydro-2',3'-dideoxythymidine; 1-(2,3-dideoxy-beta-D-glyceropent-2-enofuranosyl)thymine], FddT (3'-fluoro-3'-deoxythymidine), and AZTExpand
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Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat.
The testicular toxicity of 10 antibiotics was evaluated in juvenile rats. Three of the antibiotics, cefbuperazone, cefamandole, and cefoperazone, contain the N-methyltetrazolethiol group as theExpand
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Cardiac, Renal, and Pulmonary Toxicity of Several Mitomycin Derivatives in Rats
Abstract The potential cardiotoxicity, nephrotoxicity, and pulmonary toxicity of several mitomycin (MMC) derivatives, BMY-25067 ( N -7-[2-(4-nitrophenyl-dithio)ethyl]MMC), BMY-26107 ( NExpand
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Etoposide- and BMY-40481-Induced Sensory Neuropathy in Mice
The effects of high toxic doses of the anticancer drugs, etoposide and its phosphate derivative, BMY-40481, on the nervous system of female CD-1 mice were examined by light microscopy (LM) andExpand
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1-(2,3-Dideoxy-3-Fluoro-β-D-Ribofuranosyl)Tine (FDDT). Improved Preparation and Evaluation as a Potential Anti-Aids Agent
Abstract 3′-Deoxy-3′-fluorothymidine was prepared and evaluated as a potential anti-AIDS agent.
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The toxicological evaluation of carminomycin - an antineoplastic anthracycline antibiotic.
Carminomycin, an anthracycline antibiotic discovered in the Soviet Union, possesses antitumor activity and is chemically related to adriamycin and daunorubicin. The toxic effects of carminomycinExpand
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