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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
TLDR
The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan. Expand
Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
TLDR
It is reported here that MPTP is oxidized in the brain to a pyridinium species (a compound with potent herbicidal activity) and, in the monkey, is trapped intraneuronally and demonstrated that this enzymatic oxidation is blocked in vivo in the mouse by a monoamine oxidase inhibitor, indicating that the oxidative metabolism is required for its neurotoxic effect. Expand
Clinical presentation and pharmacological therapy in corticobasal degeneration.
TLDR
Pharmacological intervention was largely ineffective in the management of corticobasal degeneration, and new treatments are needed for ameliorating the symptoms of this syndrome. Expand
Effect of Tolcapone on Plasma Levodopa Concentrations after Coadministration with Levodopa/Carbidopa to Healthy Volunteers
TLDR
Tolcapone increased the area under the plasma concentration-time curve and half-life of levodopa approximately twofold, without appreciably increasing the peak concentration, and the maximum effect on levodOPA half- life was observed with the 200-mg dose. Expand
Biomechanic characteristics of patients with spastic and dystonic hypertonia in cerebral palsy.
TLDR
The measurement of resistance and of muscle activation during passive motion and tendon reflexes shows potential to differentiate dystonia from spasticity in CP patients with a mixed form of hypertonia. Expand
The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man.
TLDR
The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury. Expand
Impaired self‐awareness of motor deficits in Parkinson's disease: Association with motor asymmetry and motor phenotypes
TLDR
Impaired self‐awareness of motor deficits in nondemented, nondepressed Parkinson's disease patients during a defined clinical on state is investigated. Expand
Neurochemical and behavioral effects of systemic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat.
TLDR
The results indicate that NMPTP in the rat does not cause selective destruction of dopaminergic neurons, but it does produce acute tryptamine-like effects. Expand
The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
TLDR
Differences in central noradrenergic activity, reflected in cerebrospinal fluid levels of MHPG, distinguish these two forms of parkinsonism. Expand
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