• Publications
  • Influence
Life and death: metabolic rate, membrane composition, and life span of animals.
TLDR
The links between metabolic rate andmaximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span are reviewed. Expand
Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
  • R. Buffenstein
  • Biology, Medicine
  • Journal of Comparative Physiology B
  • 8 January 2008
TLDR
The naked mole-rat may be the first reported mammal showing negligible senescence over the majority of their long lifespan, and clearly physiological and biochemical processes in this species have evolved to dramatically extend healthy lifespan. Expand
The naked mole-rat: a new long-living model for human aging research.
  • R. Buffenstein
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological…
  • 1 November 2005
TLDR
Naked mole-rats are the longest-living (>28.3 years) rodents known and may provide a novel opportunity to examine mechanisms modulating aging, as well as potential use in aging research. Expand
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
TLDR
The sequencing and analysis of the naked mole rat genome is reported, which reveals unique genome features and molecular adaptations consistent with cancer resistance, poikilothermy, hairlessness and insensitivity to low oxygen, and altered visual function, circadian rythms and taste sensing. Expand
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
TLDR
It is indicated that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms. Expand
Is the naked mole-rat Hererocephalus glaber an endothermic yet poikilothermic mammal?
TLDR
The high rates of heat transfer are such that individual naked mole-rats cannot regulate Tb over the entire range of measured Tas and, as such, are poikilothermic mammals. Expand
Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research.
TLDR
Surprisingly, NMRs have high levels of oxidative stress and relatively short telomeres, yet they are extremely resilient when subjected to cellular stressors and appear capable of sustaining both their genomic and protein integrity under hostile conditions. Expand
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
TLDR
It is hypothesized that age-related changes in protein structural stability, oxidation, and degradation are abrogated over the lifespan of the MR, and pivotal mechanistic interspecies differences may contribute to the divergent aging profiles and strongly implicate maintenance of protein stability and integrity in successful aging. Expand
Acute appetite reduction associated with an increased frequency of eating in obese males
TLDR
Prolonged but attenuated increases in serum insulin concentration on the multi-meal programme may facilitate this acute reduction in appetite. Expand
Food intake and the menstrual cycle: A retrospective analysis, with implications for appetite research
TLDR
In nutrition studies involving women subjects where the menstrual cycle phase is not controlled, hormonally induced changes in food selection and intake may mask the often considerably smaller changes in response to experimental variables in appetite research. Expand
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