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Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue.
TLDR
The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility.
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Curcuma longa Extract Exerts a Myorelaxant Effect on the Ileum and Colon in a Mouse Experimental Colitis Model, Independent of the Anti-Inflammatory Effect
TLDR
Curcuma extract has a direct and indirect myorelaxant effect on mouse ileum and colon, independent of the anti-inflammatory effect, and the indirect effect is reversible and non-competitive with the cholinergic agent.
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Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
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In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors
1 The antimuscarinic effects of tripitramine were investigated in vitro in isolated driven left (force) and spontaneously beating right (force and rate) atria as well as in the ileum of guinea‐pig…
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Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes
TLDR
Here it is proposed that molecular mechanisms should be investigated, and the protective effects of some dietary flavonoids, and their metabolites are investigated, in order to determine future therapies.
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Sweet Chestnut (Castanea sativa Mill.) Bark Extract: Cardiovascular Activity and Myocyte Protection against Oxidative Damage
TLDR
In cultured cardiomyocytes the CSM bark extract reduced intracellular reactive oxygen species formation and improved cell viability following oxidative stress in dose-dependent manner and may induce cardioprotective effect.
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The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
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Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
TLDR
The universal template approach to drug design foresees that a polyamine can be modified in such a way to recognize any neurotransmitter receptor, and hybrids of polymethylene tetraamines and philanthotoxins were synthesized to produce novel inhibitors of muscular nicotinic acetylcholine receptors.
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Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range.
TLDR
One of the compounds presented presents a pharmacological profile (unprecedented nanomolar potency, high reversal of MDR, low cardiovascular activity) that makes it a promising drug candidate to treat MDR and a useful tool for studying P-glycoprotein.
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Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
TLDR
It has been confirmed that appropriate substituents on the terminal nitrogens of a tetraamine template can tune both affinity and selectivity for muscarinic receptors, and for the first time polyamines were shown to display high pA2 values also toward muscaric M3 receptors.
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