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The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
BACKGROUND Activation of Fas (CD95) by its ligand (FasL) rapidly induces cell death through recruitment and activation of caspase-8 via the adaptor protein Fas-associated death domain protein (FADD).Expand
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cFLIP regulation of lymphocyte activation and development
Cellular caspase-8 (FLICE)-like inhibitory protein (cFLIP) was originally identified as an inhibitor of death-receptor signalling through competition with caspase-8 for recruitment to FAS-associatedExpand
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Caspase Activation Is Required for T Cell Proliferation
Triggering of Fas (CD95) by its ligand (FasL) rapidly induces cell death via recruitment of the adaptor protein Fas-associated death domain (FADD), resulting in activation of a caspase cascade. ItExpand
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  • Open Access
Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.
The Pgp-1 glycoprotein was identified on a minor (27%) subset of peripheral Lyt-2+ or L3T4+ T cells. In contrast, mature medullary-type thymocytes (Lyt-2+ L3T4-, Lyt-2- L3T4+) were nearly devoid ofExpand
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Activation-induced cell death.
  • R. Budd
  • Medicine, Biology
  • Current opinion in immunology
  • 1 June 2001
The death of T lymphocytes following their activation involves several signal pathways that converge on a series of proteases, known as caspases, that degrade cellular proteins and activate a DNAse.Expand
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Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells
The immune response is capable of invoking a variety of difTerent effector mechanisms, each of which is particularly effective against a certain set of pathogens. The regulation of the type ofExpand
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CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity.
The CD2 molecule is normally expressed on nearly all murine lymphocytes, and is co-stimulatory in T cell activation via the antigen receptor (TCR). A naturally occurring T lymphocyte population thatExpand
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The CD95 Receptor: Apoptosis Revisited
CD95 is the quintessential death receptor and, when it is bound by ligand, cells undergo apoptosis. Recent evidence suggests, however, that CD95 mediates not only apoptosis but also diverseExpand
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  • Open Access
The Caspase 8 Inhibitor c-FLIPL Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes
ABSTRACT The caspase 8 inhibitor c-FLIPL can act in vitro as a molecular switch between cell death and growth signals transmitted by the death receptor Fas (CD95). To elucidate its function in vivo,Expand
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Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity
Summary Apoptotic death of T lymphocytes is critical for shutdown of immune responses and hemopoietic cell homeostasis. Both death receptor (Fas) activation and mitochondrial apoptosis triggered byExpand
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