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- Publications
- Influence
Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide.
- R. Buckheit, T. Kinjerski, +7 authors R. J. Schultz
- Biology, Medicine
- Antimicrobial agents and chemotherapy
- 1 December 1995
A series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) oxathiin carboxanilide (UC84) were evaluated for activity against the human immunodeficiency virus… Expand
2′-Fluoro-2′,3′-Dideoxyarabinosyladenine (F-ddA): Activity against Drug-Resistant Human Immunodeficiency Virus Strains and Clades A-E
- JS Driscoll, D.L. Mayers, J. Bader, O. Weislow, D. Johns, R. Buckheit
- Biology
- 1 April 1997
2′-Fluoro-2′,3′-dideoxyarabinosyladenine (F-ddA), an anti-human immunodeficiency virus (HIV) drug currently in clinical trial, was compared with zidovudine (AZT), ddl and ddC for anti-HIV activity… Expand
PMTI, a Broadly Active Unusual Single-Stranded Polyribonucleotide, Inhibits Human Immunodeficiency Virus Replication by Multiple Mechanisms
- R. Buckheit, C. Lackman-Smith, +5 authors A. D. Broom
- Biology, Medicine
- Antiviral chemistry & chemotherapy
- 1 February 1999
Poly(1-methyl-6-thioinosinic acid), or PMTI, is a single-stranded polyribonucleotide and is the first homopolyribonucleotide devoid of Watson—Crick hydrogen bonding sites to show potent human… Expand
A Diarylsulphone Non-Nucleoside Reverse Transcriptase Inhibitor with a Unique Sensitivity Profile to Drug-Resistant Virus Isolates
- R. Buckheit, V. Fliakas-Boltz, +6 authors M. Zanger
- Biology
- 1 October 1996
Structure-activity relationship evaluations with a series of diarylsulphone non-nucleoside reverse transcriptase (RT) inhibitors indicated that the steric properties of the molecule and compound… Expand