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An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
It is reported that MIF plays an important regulatory role in the activation of T cells induced by mitogenic or antigenic stimuli and assigned a previously unsuspected but critical role for MIF in antigen-specific immune responses. Expand
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis. Expand
An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect.
Cancer cells maintain a high glycolytic rate even in the presence of oxygen, a phenomenon first described over 70 years ago and known historically as the Warburg effect. Fructose 2,6-bisphosphate isExpand
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria.
Gram-positive exotoxins are extremely potent inducers of MIF secretion and establish a critical role for MIF and the macrophage in the pathogenesis of the TSSs and in the innate immune response. Expand
Migration inhibitory factor expression in experimentally induced endotoxemia.
The constitutive production of MIF by several cell and tissue types together with its rapid release from intracellular pools distinguishes MIF from other cytokines or hormonal mediators and significantly expands the physiological role of this unique counter-regulator of glucocorticoid action. Expand
Biochemical and mutational investigations of the enzymatic activity of macrophage migration inhibitory factor.
Molecular modeling of the substrate L-dopachrome methyl ester into the active site of MIF suggests an acid-catalyzed enzymatic mechanism that is different from that deduced from studies of the enzymes 4-OT and CHMI. Expand
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.
It is shown that bronchoalveolar lavage fluid obtained from asthmatic patients contains significantly elevated levels of MIF as compared to nonatopic normal volunteers and that the physiological stimuli C5a and IL-5 also cause significant MIF release. Expand
Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice.
The first experimental evidence of a role for MIF in the pathogenesis of autoimmune disease is provided, with delayed onset and lowered frequency of arthritis in mice. Expand
Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids.
These data represent the first demonstration of the cytokine MIF in human autoimmune disease and suggest MIF as a potential therapeutic target in RA. Expand
Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha.
It is reported that purified recombinant MIF activates murine macrophages to kill Leishmania major, with maximal effects at concentrations above 1 microg/ml, and the effect of MIF was blocked completely by the macrophage-deactivating cytokines IL-10, IL-13, and TGF-beta. Expand