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Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.
The complete genomic sequence of Y. pseudotuberculosis IP32953 is reported and provides a sobering example of how a highly virulent epidemic clone can suddenly emerge from a less virulent, closely related progenitor. Expand
Genome sequence of Yersinia pestis KIM.
The KIM genome sequence was compared with that of Y. pestis CO92, biovar Orientalis, revealing homologous sequences but a remarkable amount of genome rearrangement for strains so closely related, in a manner consistent with present knowledge of replication and recombination. Expand
Factors promoting acute and chronic diseases caused by yersiniae.
  • R. Brubaker
  • Biology, Medicine
  • Clinical Microbiology Reviews
  • 1 July 1991
The experimental system constructed with the medically significant yersiniae provides a powerful basic model for comparative study of factors required for expression of acute versus chronic disease.Expand
Temporal global changes in gene expression during temperature transition in Yersinia pestis.
DNA microarrays encompassing the entire genome of Yersinia pestis were used to characterize global regulatory changes during steady-state vegetative growth occurring after shift from 26 to 37 degreesExpand
Interleukin-10 and Inhibition of Innate Immunity to Yersiniae: Roles of Yops and LcrV (V Antigen)
  • R. Brubaker
  • Biology, Medicine
  • Infection and Immunity
  • 1 July 2003
Plague, caused by Yersinia pestis , is recognized as the most devastating acute infectious disease experienced by humankind. This notoriety is based upon the high rate of mortality, the rapid onset,Expand
In vivo comparison of avirulent Vwa- and Pgm- or Pstr phenotypes of yersiniae.
The results are consistent with the hypothesis that the Vwa+ phenotype favors growth within macrophages and that the Pgm+ and pesticin-sensitive phenotypes permit long-term, probably extracellular, retention within organs. Expand
Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha.
It is demonstrated that Lcr+ yersiniae suppress synthesis of cytokines and suggested that this effect is mediated by one or more Lcr plasmid-encoded virulence factors. Expand
Determination of genome size, macrorestriction pattern polymorphism, and nonpigmentation-specific deletion in Yersinia pestis by pulsed-field gel electrophoresis.
Of 16 restriction endonucleases known to hydrolyze rare 6- or 8-base recognition sequences that were tested, only SpeI, NotI, AscI, and SfiI generated fragments of chromosomal DNA from Yersinia pestis of sufficient length to permit physical analysis by pulsed-field gel electrophoresis (PFGE). Expand
Structural organization of virulence-associated plasmids of Yersinia pestis.
The complete nucleotide sequence and gene organization of the three virulence plasmids from Yersinia pestis KIM5 were determined and 30 homologues to genes of several bacterial species were found and another 44 open reading frames without homology to any known or hypothetical protein in the databases were predicted. Expand