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The S protein of bovine coronavirus is a hemagglutinin recognizing 9-O-acetylated sialic acid as a receptor determinant
TLDR
The S protein of bovine coronavirus has been isolated from the viral membrane and purified by gradient centrifugation and the potential of S protein as a probe for the detection of Neu5,9Ac2-containing glycoconjugates is demonstrated.
Complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein and its homology to histocompatibility antigens.
TLDR
It is revealed that Zn-alpha 2-glycoprotein is closely related to antigens of the major histocompatibility complex in amino acid sequence and in domain structure, and it may have a role in the expression of the immune response.
Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues.
TLDR
Data indicate that interactions of the hydroxy group at position 9 and the N-acyl substituent contribute significantly to the binding strength of the siglecs.
Use of sialic acid analogues to define functional groups involved in binding to the influenza virus hemagglutinin.
TLDR
The functional groups of the nine-carbon sialic acid molecule which interact with the hemagglutinin and contribute to the affinity of this sugar to the protein are elucidated to help develop novel compounds which bind more avidly to the influenza virus hemag GLUTinin.
Structure of the N- and O-glycans of the A-chain of human plasma alpha 2HS-glycoprotein as deduced from the chemical compositions of the derivatives prepared by stepwise degradation with
TLDR
The structure of the glycans of the A-chain of human plasma alpha 2HS-glycoprotein was established from the chemical compositions of its derivatives prepared by sequential enzymatic degradation of the carbohydrate moiety by using the distinct specificity of the highly purified exoglycosidases.
Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).
TLDR
The composition and properties of the molecules together with the known structure of the gene encoding CD43 suggest that galactoprotein is derived by proteolytic cleavage from transmembrane "hexasaccharide CD43," known to be expressed on neutrophils, activated T lymphocytes, and platelets.
Alterations in cell surface carbohydrate composition of a human colon carcinoma cell line affect adhesion to extracellular matrix components.
TLDR
The results demonstrate the existence of both RGD-dependent and carbohydrate-based mechanisms for metastatic human HT29 cell binding to collagen IV, and show that a serine-containingRGD-related peptide GRGDSP has virtually no effect on colon carcinoma cell adhesion to type IV collagen.
The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound
TLDR
By interfering with ligand binding of CD22 on the B cell surface, it is shown for the first time that the lectin domain ofCD22 has a direct, positive influence on its intracellular inhibitory domain and a novel low molecular weight compound which can enhance the response of human B cells.
A highly sensitive fluorometric assay for sialyltransferase activity using CMP-9-fluoresceinyl-NeuAc as donor.
This paper presents a very sensitive fluorometric assay for sialyltransferase activity based on the transfer of 5-acetamido-9-deoxy-9-fluoresceinylthioure-idoneuraminic acid onto distinct
Sialic acid dependent cell adhesion to collagen IV correlates with in vivo tumorigenicity of the human colon carcinoma sublines HCT116, HCT116a and HCT116b.
TLDR
Cell surface sialylation of three metastasizing sublines of a human colon carcinoma was shown to correlate with their in vivo tumorigenicity, and binding to collagen IV correlated with the in vivo aggressiveness of the cells, whereas binding to fibronectin did not.
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