R. Brock

Publications169
h-index40
Citations6,862
Highly Influential Citations286
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A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides
TLDR
Evidence is provided that the Antennapedia‐homeodomain‐derived antennapedia (Antp) peptide, nona‐arginine and the HIV‐1 Tat‐protein‐derived Tat peptide simultaneously use three endocytic pathways: macropinocytosis, clathrin‐mediated endocytotic and caveolae/lipid‐raft‐mediatedendocythesis. Expand
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
TLDR
This study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4+ T cell-mediated processes. Expand
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides*
TLDR
A triacylation pattern is necessary but not sufficient to render a lipopeptide TLR1-dependent, and a diacylation patterns is necessarybut not sufficientTo render alipopeptides TLR6-dependent. Expand
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
TLDR
The results show that a class of ATIs act as actin stabilizers and advocate that actin-dependent trafficking of auxin transport components participates in the mechanism of Auxin transport. Expand
A Stepwise Dissection of the Intracellular Fate of Cationic Cell-penetrating Peptides*
TLDR
The structural and functional data suggest a common mechanism of import for cationic cell-penetrating peptides and the toxins, which reach the cytoplasm by means of retrograde transport. Expand
Toll‐like receptor 6‐independent signaling by diacylated lipopeptides
TLDR
The results indicate that both the lipid and the N‐terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand–receptor interaction on host cells. Expand
Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration
Imaging immune surveillance by natural killer (NK) cells has revealed that integration of activating and inhibitory signals determines whether or not NK cells stop to kill the target cell or retain a… Expand
Break on through to the Other Side—Biophysics and Cell Biology Shed Light on Cell‐Penetrating Peptides
TLDR
Recent findings on the cell‐penetrating characteristics of antimicrobial peptides and the antimicrobial properties of CPPs are summarized and a perspective of how biophysics and cell biology may synergize even more efficiently in the future is concluded. Expand
Fluorescence correlation microscopy of cells in the presence of autofluorescence.
TLDR
It is concluded that FCM is a powerful, noninvasive method for probing molecular interactions in femtoliter volume elements within defined subcellular locations in living cells. Expand
High-affinity adaptors for switchable recognition of histidine-tagged proteins.
TLDR
Several supramolecular entities containing 2-4 nitrilotriacetic acid moieties were synthesized, which additionally contained an amino group, to which fluorescein was coupled as a sensitive reporter probe to create chemical recognition units. Expand
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