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A Comprehensive Model for the Cellular Uptake of Cationic Cell‐penetrating Peptides
Evidence is provided that the Antennapedia‐homeodomain‐derived antennapedia (Antp) peptide, nona‐arginine and the HIV‐1 Tat‐protein‐derived Tat peptide simultaneously use three endocytic pathways: macropinocytosis, clathrin‐mediated endocytotic and caveolae/lipid‐raft‐mediatedendocythesis.
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides*
A triacylation pattern is necessary but not sufficient to render a lipopeptide TLR1-dependent, and a diacylation patterns is necessarybut not sufficientTo render alipopeptides TLR6-dependent.
Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
- J. Dengjel, O. Schoor, S. Stevanović
- BiologyProceedings of the National Academy of Sciences…
- 13 May 2005
This study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4+ T cell-mediated processes.
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
- P. Dhonukshe, I. Grigoriev, J. Friml
- BiologyProceedings of the National Academy of Sciences
- 18 March 2008
The results show that a class of ATIs act as actin stabilizers and advocate that actin-dependent trafficking of auxin transport components participates in the mechanism of Auxin transport.
A Stepwise Dissection of the Intracellular Fate of Cationic Cell-penetrating Peptides*
- R. Fischer, Karsten Köhler, M. Fotin‐Mleczek, R. Brock
- Biology, ChemistryJournal of Biological Chemistry
- 26 March 2004
The structural and functional data suggest a common mechanism of import for cationic cell-penetrating peptides and the toxins, which reach the cytoplasm by means of retrograde transport.
Toll‐like receptor 6‐independent signaling by diacylated lipopeptides
- U. Buwitt-Beckmann, H. Heine, A. Ulmer
- Biology, ChemistryEuropean journal of immunology
- 1 January 2005
The results indicate that both the lipid and the N‐terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand–receptor interaction on host cells.
Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration
Imaging immune surveillance by natural killer (NK) cells has revealed that integration of activating and inhibitory signals determines whether or not NK cells stop to kill the target cell or retain a…
Break on through to the Other Side—Biophysics and Cell Biology Shed Light on Cell‐Penetrating Peptides
- R. Fischer, M. Fotin‐Mleczek, Hansjörg Hufnagel, R. Brock
- BiologyChembiochem : a European journal of chemical…
- 2 December 2005
Recent findings on the cell‐penetrating characteristics of antimicrobial peptides and the antimicrobial properties of CPPs are summarized and a perspective of how biophysics and cell biology may synergize even more efficiently in the future is concluded.
Fluorescence correlation microscopy of cells in the presence of autofluorescence.
High-affinity adaptors for switchable recognition of histidine-tagged proteins.
- S. Lata, A. Reichel, R. Brock, R. Tampé, J. Piehler
- Chemistry, BiologyJournal of the American Chemical Society
- 28 June 2005
Several supramolecular entities containing 2-4 nitrilotriacetic acid moieties were synthesized, which additionally contained an amino group, to which fluorescein was coupled as a sensitive reporter probe to create chemical recognition units.