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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.
TLDR
The results indicate that the expressed repertoire of IgM+ B cell subsets is shaped by recombinational bias, as well as selection before and after antigen exposure, suggesting that human peripheral blood CD5(+) andCD5(-) B cells represent different B cell lineages. Expand
Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction.
TLDR
The VH gene repertoire of human peripheral B cells was analyzed using PCR analysis of individual blood B cells, finding a bias toward VH3 and some of its members was found, indicating that it resulted from molecular and not selective processes. Expand
Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.
TLDR
The results document that the gene segment utilization within the Vkappa repertoire is biased by both intrinsic molecular processes as well as selection after light chain expression. Expand
Mutation analysis of the PTEN/MMAC1 gene in lung cancer
TLDR
The findings suggest that genetic abnormalities of the PTEN/MMAC1 gene are only involved in a relatively small subset of lung cancers. Expand
Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.
TLDR
A number of factors contributed to the nonrandom localization of mutations, including the targeting of specific motifs, such as AGY, GCY, GTA, TAY, and RGYW; an increased frequency of some commonly mutated motifs in the CDRs; and an apparent increased likelihood of mutations of CDR nucleotides. Expand
Cytokine levels in the seminal plasma of infertile males.
TLDR
The data suggest that cytokines may be involved in reduced male fertility, as cytokine levels were significantly elevated in seminal plasma exhibiting bacterial or mycoplasmal infections of the urogenital tract. Expand
Receptor revision and atypical mutational characteristics in clonally expanded B cells from the cerebrospinal fluid of recently diagnosed multiple sclerosis patients
TLDR
CSF B cell clonal expansion was detected early in the disease process and targeting of mutations to RGYW/WRCY motifs within CDRs was nominally observed in the CSf B cell clones despite the high mutational frequencies. Expand
Activated T cells acquire endothelial cell surface determinants during transendothelial migration.
TLDR
During transendothelial migration, activated T cells acquire endothelial membrane components, and as a result may deliver them to perivascular sites, and clearly involved transfer from both resting and TNF-alpha-activated EC. Expand
Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo.
TLDR
It is demonstrated that EC produce IL-15 and imply that endothelial IL- 15 plays a critical role in stimulation of T cells to extravasate into inflammatory tissue, which is in addition to its capacity to enhance accumulation of adoptively transferred human T cells in rheumatoid arthritis synovial tissue engrafted into immune deficient SCID mice. Expand
Phenotypic characterization of CD4+ T cells that exhibit a transendothelial migratory capacity.
TLDR
The results suggest that CD4+ T cells acquire the capacity for transendothelial migration at a specific phase of maturation that is only minimally altered by the activation of either the T cell or the EC, or by the presence of specific chemokines in the subendotheric matrix. Expand
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