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Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion.
It is suggested that mast cell-derived TNF-alpha may be a crucial factor in upregulating IL-6 in infiltrating leukocytes and initiating the cytokine cascade responsible for myocyte ICAM-1 induction and subsequent neutrophil-induced injury. Expand
Principles of drug therapy for the elderly patient.
The underlying reasons why the elderly population is at risk of adverse drug reactions are reviewed and the principles of drug-drug interaction, metabolism, and distribution are summarized to help elderly patients receive proper pharmacological treatment. Expand
Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus.
These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus. Expand
Effect of taurine on a muscle intracellular membrane.
Taurine slowed the rate of loss of calcium transport and ATPase activities of sarcoplasmic reticulum caused by phospholipase C, and it is suggested that taurine may function as a membrane stabilizer. Expand
Acetyl-CoA Carboxylase 2−/− Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions*
- L. Abu-Elheiga, Hongmei Wu, Ziwei Gu, R. Bressler, S. Wakil
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 February 2012
De deleting ACC2 ameliorates the metabolic syndrome and protects against fatty liver despite increased de novo lipogenesis and dietary conditions known to induce obesity and diabetes. Expand
Prevention of Diabetic Nephropathy by Diet Control in the db/db Mouse
Results indicate that diabetic control achieved by prevention of obesity in the db/db mouse prevents the development of diabetic nephropathy. Expand
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase.
- J. Bahl, M. Matsuda, R. DeFronzo, R. Bressler
- Biology, Medicine
- Biochemical pharmacology
- 10 January 1997
The results suggest the possibility that the inappropriate overproduction of glucose can be controlled by inhibitors of pyruvate carboxylase, and this class of inhibitors may be useful in the treatment of non-insulin-dependent diabetes mellitus. Expand
Clinical Pharmacology of Oral Antidiabetic Agents
The oral hypoglycemic agents available in the United States (Fig. 1) include the sulfonylureas tolbutamide (Orinase), chlorpropamide (Diabinese), acetohexamide (Dymelor), tolazamide (Tolinase) and ...
BIOCHEMICAL LESION OF DIPHTHERIA TOXIN IN THE HEART.
The pharmacology of carnitine.
The administration of cami tine as a pharmacological agent in various situations is viewed as derivative of its role in intermediary metabolism, generally related to fatty acid metabolism. Expand