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Plzf is required in adult male germ cells for stem cell self-renewal
Adult germline stem cells are capable of self-renewal, tissue regeneration and production of large numbers of differentiated progeny. We show here that the classical mouse mutant luxoid affects adultExpand
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Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse.
Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion. To testExpand
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Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice.
We have generated a transgenic mouse line,Tg(Stra8-cre)1Reb (Stra8-cre), which expresses improved Cre recombinase under the control of a 1.4 Kb promoter region of the germ cell-specific stimulated byExpand
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Androgens regulate the permeability of the blood-testis barrier.
Within the mammalian testis, specialized tight junctions between somatic Sertoli cells create basal and apical polarity within the cells, restrict movement of molecules between cells, and separateExpand
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DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNAExpand
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Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids
Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement isExpand
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Pathway to Totipotency: Lessons from Germ Cells
Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate all cell types after fertilization. Accumulating evidence suggests that this extraordinary potential isExpand
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Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.
Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are indispensable for reproduction. In the female of many species, Kiss1 neurons in the arcuate nucleusExpand
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High-throughput discovery of novel developmental phenotypes
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenitalExpand
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TEX14 is essential for intercellular bridges and fertility in male mice.
Cytokinesis in somatic cells concludes with the formation of a midbody, which is abscised to form individual daughter cells. In contrast, germ cell cytokinesis results in a permanent intercellularExpand
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