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Advanced Organic Chemistry: Reaction Mechanisms
- R. Brückner
- 26 July 2001
Radical Substitution Reactions at the Saturated C Atom Nucleophilic Substitution Reactions at the Saturated C Atom Additions to the Olefinic C=C Double Bond Eliminations Substitution Reactions on… Expand
Organic mechanisms : reactions, stereochemistry and synthesis
1 Radical Substitution Reactions at the Saturated C Atom 2 Nucleophilic Substitution Reactions at the Saturated C Atom 3 Electrophilic Additions to the C-C Double Bond 4 ss-Eliminations 5… Expand
A New Group of Aromatic Prenyltransferases in Fungi, Catalyzing a 2,7-Dihydroxynaphthalene 3-Dimethylallyl-transferase Reaction*
- Elisa Haug‐Schifferdecker, Deniz Arican, R. Brückner, L. Heide
- Biology, Medicine
- The Journal of Biological Chemistry
- 29 March 2010
Five fungal genomes from the Ascomycota (sac fungi) were found to contain a gene with sequence similarity to a recently discovered small group of bacterial prenyltransferases that catalyze the… Expand
Enantioselective Butenolide Preparation for Straightforward Asymmetric Syntheses of γ‐Lactones – Paraconic Acids, Avenaciolide, and Hydroxylated Eleutherol
The naturally occurring γ-lactones (+)-methylenolactocin (13) and its enantiomer, (+)-protolichesterinic acid (14) and its enantiomer, (+)-rocellaric acid (15), and the methylene bis(γ-lactone)… Expand
Enantioselective syntheses and configuration assignments of gamma-chiral butenolides from Plagiomnium undulatum: butenolide synthesis from tetronic acids.
Both enantiomers of the gamma-chiral alpha,beta-dimethylated butyrolactones nat-1 and nat-2 from the moss Plagiomnium undulatum were synthesized stereoselectively through butenolides and tetronic… Expand
A novel access to γ-alkylidenebutenolides: Sequential stille couplings of dibromomethylenebutenolides
γ-(Dibromomethylene)butenolide (2) and β-bromo-γ-(bromomethylene)butenolide (Z-5), both of which obtained from dibromolevulinic acid (6) in a single step, underwent Pd-catalyzed couplings with… Expand
Synthesis and biological effects of new hybrid compounds composed of benzylguanidines and the alkylating group of busulfan on neuroblastoma cells.
- T. Hampel, M. Bruns, M. Bayer, R. Handgretinger, G. Bruchelt, R. Brückner
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 June 2014
(131)Iodine-labelled (meta-iodobenzyl)guanidine ([(131)I]-mIBG) and busulfan [butane-1,4-diylbis(methanesulfonate)] are well-established pharmaceuticals in neuroblastoma therapy. We report the… Expand
Synthesis, pharmacological characterization, and quantitative structure-activity relationship analyses of 3,7,9,9-tetraalkylbispidines: derivatives with specific bradycardic activity.
- U. Schön, J. Antel, R. Brückner, J. Messinger, R. Franke, A. Gruska
- Chemistry, Medicine
- Journal of medicinal chemistry
- 6 January 1998
A series of 3,7,9,9-tetraalkyl-3,7-diazabicyclo[3.3.1]nonane derivatives (bispidines) was synthesized and identified as potential antiischemic agents. Pharmacological experiments in vitro as well as… Expand