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Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection
Background— 5′AMP-activated protein kinase (AMPK), a well-known regulator of cellular energy status, is also implicated in ischemic preconditioning leading to cardioprotection. We hypothesized thatExpand
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Investigation and control of a cluster of cases of Legionnaires disease in western Sydney.
Three cases of Legionella pneumophila infection were identified in Sydney's west in November 1998. Epidemiological investigations identified an association with one workplace. Environmental samplingExpand
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SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.
Recent evidence suggests that oxidative stress is a common denominator in many aspects of cardiovascular pathogenesis. Free cellular iron plays a crucial catalytic role in the formation of highlyExpand
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Reactive Oxygen Species Precede Protein Kinase C-&dgr; Activation Independent of Adenosine Triphosphate–sensitive Mitochondrial Channel Opening in Sevoflurane-induced Cardioprotection
BackgroundIn the current study, the authors investigated the distinct role and relative order of protein kinase C (PKC)-&dgr;, adenosine triphosphate–sensitive mitochondrial K+ (mito K+ATP) channels,Expand
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Beat-to-Beat Hemodynamic Monitoring During Electroconvulsive Therapy
Objectives: Rapid parasympathetic and sympathetic hemodynamic effects during electroconvulsive therapy (ECT) may pose vulnerable patients to significant risk for cardiovascular complications. Here,Expand
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High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study
BackgroundGlucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucoseExpand
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Anaesthetic management during open and percutaneous irreversible electroporation.
BACKGROUND Irreversible electroporation (IRE) is a novel tumour ablation technique involving repetitive application of electrical energy around a tumour. The use of pulsed electrical gradientsExpand
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Ablation of colorectal liver metastases by irreversible electroporation: results of the COLDFIRE-I ablate-and-resect study
ObjectivesIrreversible electroporation (IRE) is a new ablation technique that relies on high-voltage electrical pulses. This clinical study evaluates the pathological response of colorectal liverExpand
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Cardioprotection Via Activation of Protein Kinase C-&dgr; Depends on Modulation of the Reverse Mode of the Na+/Ca2+ Exchanger
Background— Pretreatment with the volatile anesthetic sevoflurane protects cardiomyocytes against subsequent ischemic episodes caused by a protein kinase C (PKC)-&dgr; mediated preconditioningExpand
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Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species.
BACKGROUND We previously demonstrated the involvement of the Ca2+-independent protein kinase C-delta (PKC-delta) isoform in sevoflurane-induced cardioprotection against ischaemia and reperfusionExpand
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