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Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection
Background— 5′AMP-activated protein kinase (AMPK), a well-known regulator of cellular energy status, is also implicated in ischemic preconditioning leading to cardioprotection. We hypothesized that… Expand
Investigation and control of a cluster of cases of Legionnaires disease in western Sydney.
- J. Brown, K. Hort, +5 authors S. Vemulpad
- Communicable diseases intelligence quarterly…
- 1 April 2001
Three cases of Legionella pneumophila infection were identified in Sydney's west in November 1998. Epidemiological investigations identified an association with one workplace. Environmental sampling… Expand
SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.
- T. Šimůnek, C. Boer, +9 authors R. Musters
- Medicine, Chemistry
- Journal of molecular and cellular cardiology
- 1 August 2005
Recent evidence suggests that oxidative stress is a common denominator in many aspects of cardiovascular pathogenesis. Free cellular iron plays a crucial catalytic role in the formation of highly… Expand
Reactive Oxygen Species Precede Protein Kinase C-&dgr; Activation Independent of Adenosine Triphosphate–sensitive Mitochondrial Channel Opening in Sevoflurane-induced Cardioprotection
- R. Bouwman, R. J. Musters, B. J. van Beek-Harmsen, J. J. de Lange, C. Boer
- 1 March 2004
BackgroundIn the current study, the authors investigated the distinct role and relative order of protein kinase C (PKC)-&dgr;, adenosine triphosphate–sensitive mitochondrial K+ (mito K+ATP) channels,… Expand
Beat-to-Beat Hemodynamic Monitoring During Electroconvulsive Therapy
Objectives: Rapid parasympathetic and sympathetic hemodynamic effects during electroconvulsive therapy (ECT) may pose vulnerable patients to significant risk for cardiovascular complications. Here,… Expand
High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study
- C. E. van den Brom, C. Bulte, B. M. Kloeze, S. Loer, C. Boer, R. Bouwman
- Cardiovascular Diabetology
- 20 June 2012
BackgroundGlucose intolerance is a major health problem and is associated with increased risk of progression to type 2 diabetes mellitus and cardiovascular disease. However, whether glucose… Expand
Ablation of colorectal liver metastases by irreversible electroporation: results of the COLDFIRE-I ablate-and-resect study
ObjectivesIrreversible electroporation (IRE) is a new ablation technique that relies on high-voltage electrical pulses. This clinical study evaluates the pathological response of colorectal liver… Expand
Anaesthetic management during open and percutaneous irreversible electroporation.
BACKGROUND Irreversible electroporation (IRE) is a novel tumour ablation technique involving repetitive application of electrical energy around a tumour. The use of pulsed electrical gradients… Expand
Cardioprotection Via Activation of Protein Kinase C-&dgr; Depends on Modulation of the Reverse Mode of the Na+/Ca2+ Exchanger
Background— Pretreatment with the volatile anesthetic sevoflurane protects cardiomyocytes against subsequent ischemic episodes caused by a protein kinase C (PKC)-&dgr; mediated preconditioning… Expand
Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species.
BACKGROUND We previously demonstrated the involvement of the Ca2+-independent protein kinase C-delta (PKC-delta) isoform in sevoflurane-induced cardioprotection against ischaemia and reperfusion… Expand