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Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory.
In an attempt to improve behavioral memory, we devised a strategy to amplify the signal-to-noise ratio of the cAMP pathway, which plays a central role in hippocampal synaptic plasticity andExpand
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A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4
Mice carrying a truncated form of cAMP-responsive element binding protein (CREB)-binding protein (CBP) show several developmental abnormalities similar to patients with Rubinstein-Taybi syndromeExpand
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Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory
Learning-induced synaptic plasticity commonly involves the interaction between cAMP and p42/44MAPK. To investigate the role of Rap1 as a potential signaling molecule coupling cAMP and p42/44MAPK, weExpand
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Rubinstein-Taybi syndrome: molecular findings and therapeutic approaches to improve cognitive dysfunction
Abstract.Rubinstein-Taybi syndrome (RTS) is a rare human genetic disorder characterized by mental retardation and physical abnormalities. Many RTS patients have a genetic mutation which has beenExpand
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A Novel Phosphodiesterase Type 4 Inhibitor, HT-0712, Enhances Rehabilitation-Dependent Motor Recovery and Cortical Reorganization After Focal Cortical Ischemia
Rehabilitation-dependent motor recovery after cerebral ischemia is associated with functional reorganization of residual cortical tissue. Recovery is thought to occur when remaining circuitryExpand
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RNA interference in hippocampus demonstrates opposing roles for CREB and PP1α in contextual and temporal long‐term memory
We injected small interfering RNAs (siRNAs) directly into the hippocampus of wild‐type mice, knocking down expression of cyclic AMP responsive element‐binding protein (CREB) and disrupting long‐term,Expand
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Memories are Made of This: The Biological Building Blocks of Memory
Every memory, from our first recollection of a family event, to our response to the ring of a doorbell, defines who we are. Without memory constantly linking the threads of our present, past andExpand
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Methodes de criblage de nootropes
La presente invention se rapporte a des methodes d'identification de nootropes capables d'ameliorer le fonctionnement de la voie CREB. Les nootropes identifies selon l'invention peuvent etre utilisesExpand