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Two-component signal transduction.
Ruth Silversmith is a research associate professor in the Department of Microbiology and Immunology at the University of North Carolina, Chapel Hill. She brings a biochemistry and biophysics… Expand
Receiver domain structure and function in response regulator proteins.
- R. Bourret
- Biology, Medicine
- Current opinion in microbiology
- 1 April 2010
During signal transduction by two-component regulatory systems, sensor kinases detect and encode input information while response regulators (RRs) control output. Most receiver domains function as… Expand
Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance
WE have used surface plasmon resonance biosensor technology to monitor the assembly and dynamics of a signal transduction complex which controls chemotaxis in Escherichia coli A quaternary complex… Expand
Signal Transduction via the Multi-Step Phosphorelay: Not Necessarily a Road Less Traveled
It is worth noting that the reported phosphorelays, as well as the putative phosphorelay candidates mentioned above, govern major developmental commitments, decisions that should not be lightly made.… Expand
Signal transduction pathways involving protein phosphorylation in prokaryotes.
Bacteria are capable of sensing a wide variety of environmental signals, including changes in chemical concentrations, the presence of a host organism, or variation in physical parameters such as… Expand
Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY.
The CheY protein is phosphorylated by CheA and dephosphorylated by CheZ as part of the chemotactic signal transduction pathway in Escherichia coli. Phosphorylation of CheY has been proposed to occur… Expand
Molecular Information Processing: Lessons from Bacterial Chemotaxis*
Extracellular information is converted into a usable intracellular form via signal transduction. This critically important process occurs in both unicellular and multicellular organisms throughout… Expand
Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis
A cascade of protein phosphorylation, initiated by autophosphorylation of the CheA protein, may be important in the signal transduction pathway of bacterial chemotaxis. A proteolytic fragment of CheA… Expand
Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ
The protein CheZ, which has the last unknown structure in the Escherichia coli chemotaxis pathway, stimulates the dephosphorylation of the response regulator CheY by an unknown mechanism. Here we… Expand
Computer simulation of the phosphorylation cascade controlling bacterial chemotaxis.
We have developed a computer program that simulates the intracellular reactions mediating the rapid (nonadaptive) chemotactic response of Escherichia coli bacteria to the attractant aspartate and the… Expand