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Cardiotoxicity of anthracyclines.
The statistical analysis of data showed an equivalent inhibitory effect between adriamycin and esorubicin, whereas 4-epiadriamcin has in normodynamic conditions greater negative inotropic effects significantly different from that of the two other drugs.
Antinociceptive effect of centrally administered cimetidine and dimaprit in the rat.
It is suggested that the analgesic action of cimetidine and dimaprit is not due to specific effects on H2 receptors, and that the specific opioid antagonist naloxone was without effect.
Potential antitumor agents XIX . Synthesis and antitumor activity of tricyclic compounds related to lotifazole.
- A. Andreani, M. Rambaldi, A. Locatelli, A. Fraccari, R. Bossa, I. Galatulas
- Chemistry, BiologyPharmaceutica acta Helvetiae
The synthesis of phenothiazine and anthraquinone derivatives, bearing at least one fragment present in lotifazole, is reported. Some of the new compounds showed antitumor activity in vitro (P388…
Effect of various antitumor drugs on energetic processes.
Potential antitumor agents IX: synthesis and antitumor activity of two analogues of ketocaine.
- A. Andreani, G. Scapini, I. Galatulas, R. Bossa
- Chemistry, BiologyJournal of pharmaceutical sciences
- 1 July 1983
The reaction between o-hydroxybutyrophenone and tris(2-chloroethyl)amine gave two analogues (II, V) of the well-known local anesthetic ketocaine (I). Compounds II and V showed interesting antitumor…
Potential antitumor agents. 25 . Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones.
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of…
Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
Interaction between Doxorubicin and Mitomycin C on Mortality and Myocardial Contractility in Guinea PIG
- E. Monti, R. Bossa, I. Galatulas, L. Favalli, Fabrizio Villan, F. Piccinini
- Biology, ChemistryTumori
- 1 April 1983
The present investigations were carried out in guinea pig to ascertain whether mitomycin C has a direct cardiotoxic effect or interacts with doxorubicin-induced cardiotoxicity, and results do not support the possibility that mitomyin C potentiates the acute cardiot toxic effects produced by doxorbicin.
Synthesis and cardiotonic activity of imidazo[2,l-b]thiazoles bearing a lactam ring