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Natural products research: perspectives from a major pharmaceutical company.
- R. Borris
- ChemistryJournal of ethnopharmacology
- 1 April 1996
Natural product drug discovery and development: new perspectives on international collaboration.
A discussion of policies for international collaboration and compensation being implemented by several developed country organizations, and the perspectives on the current developments given by representatives of some of the source countries located in the regions of greatest biodiversity.
Ethnopharmacologic and phytochemical studies of the Thymelaeaceae.
Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.
Correolide is the first potent, small molecule inhibitor of Kv1 series channels to be identified from a natural product source and will be useful as a probe for studying potassium channel structure and the physiological role of such channels in target tissues of interest.
Contemporary Pacific and Western perspectives on `awa (Piper methysticum) toxicology.
L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination.
Rediocides B-E, potent insecticides from Trigonostemon reidioides.
Four new congeners, rediocides B-E (2-5), of the previously reported rediocide A were isolated from a methanol extract of the roots of the plant Trigonostemon reidioides, and possess potent activity against fleas in an artificial membrane feeding system.
Novel nematocidal agents from Curcuma comosa.
Five diphenylheptanoids, one new and four known, have been isolated and shown to be responsible for the activity of Curcuma comosa and this is the first report of three of these compounds being isolated from a natural source.
NMR Spectral Analysis of Cadambine from Anthocephalus chinensis