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Chiral drugs: an industrial analytical perspective.
Issues related to method development and validation for complete stereochemical characterization are discussed, with primary emphasis on the generation of analytical data required for the registration of a chiral drug candidate. Expand
Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.
This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detectionExpand
Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans.
The enantiomeric composition of benoxaprofen [(RS)-2-(P-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid] in plasma and urine was determined after oral administration of both the racemic mixtureExpand
Quantitation of propoxyphene and its major metabolites in heroin addict plasma after large dose administration of propoxyphene napsylate.
A sensitive and specific GLC assay method was developed for the determination of propoxyphene, its major metabolite norpropoxyphene, and lesser known metabolites cyclic dinorpropoxyphene and/orExpand
Linear pharmacokinetics of orally administered fenoprofen calcium.
Physical measurements of each capsule formulation drug content, weight variation, and dissolution showed the products to be uniform and readily soluble and linearity of kinetics for fenoprofen in plasma throughout the 60--300-mg dosage range after a single dose. Expand
Practical aspects of LC/EC determinations of pharmaceuticals in biological media
Abstract Liquid chromatography with electrochemical detection (LC/EC) has proven itself to be a very useful technique for the determination of electrochemically oxidizable or reducible compounds inExpand
Optimization of a capillary electrophoresis method to determine the chiral purity of a drug
Abstract Capillary electrophoresis (CE) using hydroxypropyl-β-cyclodextrin (HP-β-CD) in the separation buffer was investigated to determine the overall chiral purity of a drug containing a singleExpand
GLC determination of dl-2-(3-phenoxyphenyl)propionic acid (Fenoprofen) in human plasma.
The quantitative determination of dl-2-(3-phenoxyphenyl)propionic acid (fenoprofen) in plasma is described and plasma data are presented to demonstrate the clinical utility of the method. Expand
Determination of enviroxime in a variety of biological matrixes by liquid chromatography with electrochemical detection.
  • R. Bopp, D. Miner
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 December 1982
This method has proven to be applicable and reliable for the determination of enviroxime in many types of biological samples and several problems encountered during the routine use of electrochemical detection were explored and minimized. Expand