R. Boonstra

Publications13
h-index9
Citations1,099
Highly Influential Citations48
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The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
Adult animals continue to produce new neurons in the dentate gyrus of hippocampus. Until now, the principal method of studying neurogenesis has been to inject either tritiated thymidine or… Expand
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Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive.
Chromosomal translocations involving t(14;18)(q32;q21) and the chromosome 3q27 region are common in B-cell non-Hodgkin lymphoma of germinal center cell origin. Grade 3B follicular lymphoma (FL),… Expand
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Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma?
We studied a histological homogeneous group of 29 cases with the diagnosis of follicular lymphoma (FL) grade 3B (FL3Bs). In a previous study, we subdivided this group in 3 subgroups based on (1)… Expand
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Splenic Marginal Zone Lymphomas Presenting with Splenomegaly and Typical Immunophenotype Are Characterized by Allelic Loss in 7q31–32
Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin’s lymphoma that recently has been recognized as an entity. The first goal of this study was to identify potential chromosomal aberrations… Expand
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Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation
The aim of this study was to find factors that could explain the accumulation difference of mitoxantrone in the BCRP1-negative GLC4-MITO cell line compared to GLC4. Comparative genomic hybridisation… Expand
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BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B
Translocations involving band 3q27, affecting the major breakpoint region (MBR) of BCL6, are common in diffuse large B‐cell lymphomas (DLBCLs). Recent data suggest an alternative breakpoint cluster… Expand
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Identification of chromosomal copy number changes associated with transformation of follicular lymphoma to diffuse large B-cell lymphoma.
The histological transformation from a follicular lymphoma (FL) to a diffuse large B-cell lymphoma (DLBL) occurs in 22% to 30% of all cases of FL. The aim of this study was to identify specific… Expand
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Effect of B‐cell receptor engagement on CD40‐stimulated B cells
Activation of human B cells in vitro either by cross‐linking of surface immunoglobulins (sIg) or by triggering CD40 antigen, in the presence of interleukin‐10 (IL‐10) and interleukin‐2 (IL‐2), may… Expand
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Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas: frequent loss of chromosome arm 6q
Primary central nervous system lymphoma (PCNSL) is a rare disease. A small number of cytogenetic studies of PCNSL have been conducted and several reports have been published on associated molecular… Expand
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Follicular lymphoma grade 3B includes three cytogenetically defined subgroups with primary t(14;18), 3q27 or other translocations
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