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Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination
Homing in on Hotspots The clustering of recombination in the genome, around locations known as hotspots, is associated with specific DNA motifs. Now, using a variety of techniques, three studiesExpand
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IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex
The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years. Expand
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IMGT, the International ImMunoGeneTics database
IMGT, the international ImMunoGeneTics database, is an integrated database specializing in immunoglobulins, T-cell receptors (TcR) and major histocompatibility complex (MHC) of all vertebrate species, initiated and co-ordinated by Marie-Paule Lefranc, CNRS, Montpellier II University. Expand
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Intra- and Interspecific Variation in Primate Gene Expression Patterns
Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects.Expand
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Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination wasExpand
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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees
Balancing Humans with Apes Shared ancestral polymorphisms between species tend to be relatively rare, and studies of trans-species polymorphisms have focused on just a few regions known for balancingExpand
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A Fine-Scale Chimpanzee Genetic Map from Population Sequencing
Going Ape Over Genetic Maps Recombination is an important process in generating diversity and producing selectively advantageous genetic combinations. Thus, changes in recombination hotspots mayExpand
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Nomenclature for factors of the HLA system, 2010
The WHO Nomenclature Committee for Factors of the HLA System met following the 14th International HLA and Immunogenetics Workshop in Melbourne, Australia in December 2005 and Buzios, Brazil duringExpand
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Diversity of microRNAs in human and chimpanzee brain
We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyondExpand
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Strong male bias drives germline mutation in chimpanzees
Male chimps evolve faster with age Chimpanzees are evolving faster than humans. Venn et al. examined the genetics of three generations of western chimpanzees and found that overall the mutation rateExpand
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