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Extended-Spectrum β-Lactamases: a Clinical Update
SUMMARY Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are inhibited byExpand
Three Decades of β-Lactamase Inhibitors
SUMMARY Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantlyExpand
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria,Expand
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
We may soon be facing the end of the “antibiotic era.” The initial and seemingly unstoppable success of antibiotics, the fruit of human ingenuity, has been countered by an escalation of resistanceExpand
Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.
The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii has raised concern in health care settings worldwide. In order to understand the repertoire of resistance determinantsExpand
Carbapenems: Past, Present, and Future
ABSTRACT In this review, we summarize the current “state of the art” of carbapenem antibiotics and their role in our antimicrobial armamentarium. Among the β-lactams currently available, carbapenemsExpand
“Stormy waters ahead”: global emergence of carbapenemases
Carbapenems, once considered the last line of defense against of serious infections with Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem-resistantExpand
Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients.
BACKGROUND Colonization and infection with vancomycin-resistant enterococci have been associated with exposure to antibiotics that are active against anaerobes. In mice that have intestinalExpand
Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding.
Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spreadExpand
Genetic analysis of surface motility in Acinetobacter baumannii.
The Gram-negative pathogen Acinetobacter baumannii strain M2 was found to exhibit a robust surface motility on low-percentage (0.2-0.4 %) agar plates. These patterns of motility were dramaticallyExpand