• Publications
  • Influence
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of
TLDR
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality. Expand
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of
An American College ofChest Physicians/Society ofCritical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of de6nitions that could beExpand
The ACCP-SCCM consensus conference on sepsis and organ failure.
TLDR
Only recently has the knowledge of the molecular and cellular events that occur in sepsis and its sequelae begun to shed light on the complex cascade of events underlying these disorders. Expand
Immunologic Dissonance: A Continuing Evolution in Our Understanding of the Systemic Inflammatory Response Syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome (MODS)
  • R. Bone
  • Medicine
  • Annals of Internal Medicine
  • 15 October 1996
TLDR
It is true that the underlying inflammatory reaction is vastly more complicated than the authors had thought, and it is unlikely that a magic bullet will be found soon, but by reexamining what they have learned and rethinking their assumptions, they can better understand how organ dysfunction develops and how to prevent it. Expand
Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome
TLDR
Study of lipopolysaccharide and cytokine levels in 97 patients with the sepsis syndrome found a positive correlation between high levels of plasma TNF- and mortality, and implicate T NF- as an important mediator in sepsi. Expand
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.
TLDR
High-dose antithrombin III therapy had no effect on 28-day all-cause mortality in adult patients with severe sepsis and septic shock when administered within 6 hours after the onset. Expand
Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome)
  • R. Bone
  • Medicine
  • JAMA
  • 23 December 1992
TLDR
Patients with severe SIRS should not be assumed to have gram-negative infection; furthermore, data derived from studies of patients with gram- negative infection should be applied cautiously to all patients with SirS. Expand
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
TLDR
It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock. Expand
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