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Physiology and pathophysiology of matrix metalloproteases
TLDR
An overview of 23 members of the human MMP family is given and functions, linkages to disease and structural and mechanistic features are described. Expand
Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.
TLDR
The main nitration reactions and elucidate why nitration is not a random chemical process are reviewed and the possibility of an in vivo denitration process is indicated. Expand
Identification of a heparin-binding hemagglutinin present in mycobacteria
TLDR
It is shown that binding of mycobacteria to epithelial cells but not to macrophages can be specifically inhibited by sulfated carbohydrates, which may provide the basis for the development of new therapeutic and prophylactic strategies againstMycobacterial diseases. Expand
Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer.
TLDR
Targeting cytoplasmic p21, including by modulation of the Oct4/miR-106b/p21 pathway, may offer new strategies for the treatment of chemoresistant testicular and other types of cancer. Expand
Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.
TLDR
The review discusses the structural domains that are not directly linked to protease activity followed by a more detailed overview over the role of the metalloprotease domain. Expand
Receptor-ligand binding assays: technologies and applications.
TLDR
Applications of receptor-ligand binding assays described in this review will relate to screening and the quantification of pharmaceuticals in biological matrices. Expand
Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples.
TLDR
An understanding of the biological variation of proteins and metabolites in CSF of neurologically normal individuals appears to be essential for reliable interpretation of biomarker discovery studies for CNS disorders because such results may be influenced by natural inter-individual variations. Expand
Molecular characterization of the mycobacterial heparin-binding hemagglutinin, a mycobacterial adhesin.
TLDR
Glycosylation of HBHA appears to protect the protein from proteolytic degradation, which results in the removal of the C-terminal Lys/Pro-rich region responsible for binding ofHBHA to sulfated carbohydrates. Expand
A Critical Assessment of Feature Selection Methods for Biomarker Discovery in Clinical Proteomics*
TLDR
It is concluded that the univariate t test and the mww test with multiple testing corrections are not applicable to data sets with small sample sizes, but their performance improves markedly with increasing sample size up to a point at which they outperform the other methods. Expand
A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata).
TLDR
A 38-residue peptide is isolated from this hemolymph of dragonflies which is strongly active against Gram-positive bacteria and also shows activity against one of the Gram-negative bacteria which was tested. Expand
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