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SH2 domains recognize specific phosphopeptide sequences
View on Elsevier
Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
TLDR
Structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.
View on Springer
Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation*
TLDR
It is demonstrated that, despite their similarity, TYRO3, AXL, and MER are likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs.
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Fas engagement induces neurite growth through ERK activation and p35 upregulation
TLDR
It is reported that crosslinking Fas on primary sensory neurons induces neurite growth through sustained activation of the extracellular-signal regulated kinase (ERK) pathway and the consequent upregulation of p35, a mediator of neurite outgrowth.
View on Nature
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
TLDR
Results have revealed the Rho-dependent Rac activation signaling that is mediated by mDia1 through Cas phosphorylation and antagonized by the action of ROCK.
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Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
TLDR
The biology of phosphatidylserine is discussed with respect to its role as a global immunosuppressive signal and how PS is exploited to drive diverse pathological processes such as infection and cancer.
View on Nature
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts
TLDR
Data suggest that paxillin is involved in a highly dynamic kinase-phosphatase interplay in normal CEF and that v-Crk binding may interrupt this balance to increase the steady-state level of tyrosine phosphorylation.
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αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells
TLDR
The αvβ5 receptor mediates both binding and internalization of apoptotic cells and is linked to the CrkII–Dock180–Rac1 molecular complex in mammalian cells, revealing an evolutionarily conserved signalling pathway that is responsible for the recognition and internalized of apoptosis by both professional and non-professional phagocytes.
View on Nature
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
TLDR
The main molecular, immunological, preclinical, and clinical aspects of ICD are summarized and tabulate in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
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The Adapter Type Protein CMS/CD2AP Binds to the Proto-oncogenic Protein c-Cbl through a Tyrosine Phosphorylation-regulated Src Homology 3 Domain Interaction*
TLDR
Immunofluorescence analysis revealed that both proteins colocalize at lamellipodia and leading edges of cells, and it is proposed that the interaction of CMS with c-Cbl offers a mechanism by which c- Cbl associates and regulates the actin cytoskeleton.
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