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Delivery of the tumour photosensitizer zinc(II)-phthalocyanine to serum proteins by different liposomes: studies in vitro and in vivo.
A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE
The in vivo measurements at two different anatomical sites showed pharmacokinetic behavior that reflects an overall integrated fluorescence originating from several tissue sites, consistent with previous findings on the pharmacokinetics of ZnPc.
Liposome‐Mediated Delivery of Photosensitizers: Localization of Zinc (11)‐Phthalocyanine within Implanted Tumors after Intravenous Administration
- W. Love, S. Duk, R. Biolo, G. Jori, P. Taylor
- Medicine, BiologyPhotochemistry and photobiology
- 1 May 1996
The photosensitizer was found in association with blood vessels at 3 h but not 24 h after dosing and appeared to have a greater affinity for areas of tissue necrosis within the tumor compared to viable tumor tissue.
Photoinactivation of amelanotic and melanotic melanoma cells sensitized by axially substituted Si-naphthalocyanines.
Liposome- or LDL-administered Zn (II)-phthalocyanine as a photodynamic agent for tumours. I. Pharmacokinetic properties and phototherapeutic efficiency.
- E. Reddi, C. Zhou, R. Biolo, E. Menegaldo, G. Jori
- Biology, MedicineBritish Journal of Cancer
- 1 March 1990
It is found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose, and PDT gives satisfactory results even if performed at relatively long time intervals after administration.
Zn(II)-phthalocyanine as a photodynamic agent for tumours. II. Studies on the mechanism of photosensitised tumour necrosis.
The hypothesis that low density lipoproteins (LDL) play a major role in the delivery of Zn-Pc to the tumour tissue is supported; the photosensitiser is released specifically to malignant cells as a consequence of a receptor-mediated endocytosis of LDL.
Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
Zn(II)-phthalocyanine incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally to BALB/c mice bearing a transplanted MS-2 fibrosarcoma to discuss a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours.
ULTRASTRUCTURAL STUDIES ON THE MECHANISM OF THE PHOTODYNAMIC THERAPY OF TUMORS
- C. Milanesi, R. Biolo, E. Reddi, G. Jori
- Biology, ChemistryPhotochemistry and photobiology
- 1 November 1987
The ultrastructural analysis of tumor specimens taken from mice at 15 h after PDT showed that TPPS photoinduces a preferential necrosis of the neoplastic cells, while Zn‐Pc causes severe photodamage to both the vascular system and the neoperastic cells.
Effect of Photosensitizer Delivery System and Irradiation Parameters on the Efficiency of Photodynamic Therapy of B16 Pigmented Melanoma in Mice
- R. Biolo, G. Jori, M. Soncin, B. Rihter, M. Kenney, M. Rodgers
- Chemistry, BiologyPhotochemistry and photobiology
- 1 February 1996
Investigation of liposome‐delivered Si(IV)‐na‐phthalocyanine photosensitizes B16 pigmented melanoma subcutaneously transplanted in C57 mice to the action of 776 nm light shows that the efficacy of the phototreatment was limited by a lack of selectivity of tumor targeting by SiNc as well as by incomplete necrosis of the neoplastic mass.
PHOTODYNAMIC THERAPY OF B16 PIGMENTED MELANOMA WITH LIPOSOME‐DELIVERED Si(IV)‐NAPHTHALOCYANINE
The possibility of extending photodynamic therapy to the treatment of highly pigmented neoplastic lesions was tested by using Si(IV)‐naphthalocyanine (SiNc) as a tumor‐localizing agent, which appears to be of purely photochemical nature at dose rates up to 260 mW cm−2.