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Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
- S. R. Mulay, Jyaysi Desai, +18 authors H. Anders
- Biology, Medicine
- Nature communications
- 28 January 2016
Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium… Expand
Blood serum immunoglobulins of patients with multiple myeloma are capable of hydrolysing histone H1.
- I. Magorivska, R. Bilyy, O. Shalay, V. Loginsky, Y. Kit, R. Stoika
- Chemistry, Medicine
- Experimental oncology
- 1 June 2009
BACKGROUND Recently we have shown that the imunoglobulins G from blood serum of some multiple sclerosis patients are capable of cleaving histone H1. AIM To check whether histone H1-hydrolyzing… Expand
Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors
Introduction Many antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and… Expand
Alterations in carbohydrate determinants in rat adrenal gland following experimental hypothyroidism
Thyroid disorders are currently among the most widespread endocrine pathologies, affecting about 3% of the world’s population. Although the thyroid gland interacts with other endocrine organs,… Expand
Water-soluble pristine fullerenes C60 increase the specific conductivity and capacity of lipid model membrane and form the channels in cellular plasma membrane.
- S. Prylutska, R. Bilyy, +7 authors U. Ritter
- Materials Science, Medicine
- Journal of biomedical nanotechnology
- 1 June 2012
The aim of the present work was the investigation of the interaction of water-soluble pristine fullerenes C60 with bimolecular lipid model membrane (BLM) and cellular plasma membrane (PM). The… Expand
AMID: new insights on its intracellular localization and expression at apoptosis
AMID (apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death) is a poorly studied member of the AIF family; despite the given name AMID, predicting its association with… Expand
Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation
Necrosis is associated with a profound inflammatory response. The regulation of necrosis-associated inflammation, particularly the mechanisms responsible for resolution of inflammation is… Expand
Comparative study of human breast carcinoma MCF-7 cells differing in their resistance to doxorubicin: effect of ionizing radiation on apoptosis and TGF-beta production.
AIM The aim of the study was to investigate the survival and growth of human breast carcinoma MCF-7 cells with different sensitivity to doxorubicin and production of transforming growth factor… Expand
UVB-irradiated apoptotic cells induce accelerated growth of co-implanted viable tumor cells in immune competent mice
The presence of a solid tumor is the result of a complex balance between rejection, tolerance and regeneration in which the interactions of tumor cells with cells of the host immune system contribute… Expand
Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation
Neutrophils form neutrophil extracellular traps (NETs) of decondensed DNA and histones that trap and immobilize particulate matter and microbial pathogens like bacteria. NET aggregates reportedly… Expand