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Construction of a 3D probabilistic atlas of human cortical structures
The construction of a digital brain atlas composed of data from manually delineated MRI data, providing a resource for automated probabilistic labeling of external data types registered into standard spaces, and computed average intensity images and tissue density maps based on the three methods and target spaces.
Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates.
A large generalized deficit and more subtle differential deficits were observed even in patients with less severe generalized deficit, but the pattern was unlike the amnestic syndrome and probably reflects different mechanisms.
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes
It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.
Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder.
Although some patients with first-episode schizophrenia can achieve sustained symptomatic and functional recovery, the overall rate of recovery during the early years of the illness is low.
Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder.
There is a high rate of relapse within 5 years of recovery from a first episode of schizophrenia and schizoaffective disorder, and this risk is diminished by maintenance antipsychotic drug treatment.
Adolescent immaturity in attention-related brain engagement to emotional facial expressions
It is suggested that adults show greater modulation of activity in relevant brain structures based on attentional demands, whereas adolescents exhibit greater modulation based on emotional content.
Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder.
Findings of reduced orbital frontal and amygdala volumes in patients implicate a structural abnormality of these brain regions in the pathophysiology of OCD and Absence of the normal hemispheric asymmetry of the hippocampus-amygdala complex in patients is consistent with an anomalous neurodevelopmental process.
Longitudinal study of brain morphology in first episode schizophrenia
The finding of progressive ventricular enlargement in patients with poor outcome schizophrenia is consistent with the hypothesis that persistent positive and negative symptoms result in progressive brain changes in the form of ventricular enlargeement, possibly due to neurodegeneration rather than the confounding effects of treatment.
Mapping cortical thickness and gray matter concentration in first episode schizophrenia.
We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72
Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial.
After 2 months of antipsychotic treatment, all groups had a small but significant improvement in neurocognition, and after 18 months of treatment, neurocognitive improvement was greater in the perphenazine group than in the olanzapine and risperidone groups.