R. Biggar

Publications381
h-index85
Citations25,309
Highly Influential Citations831
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Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome.
TLDR
HPV-associated malignancies occur at increased rates in persons with HIV/AIDS, and increasing RRs for in situ cancers to and beyond the time of AIDS onset may reflect the gradual loss of control over HPV-infected keratinocytes with advancing immunosuppression.
View on PubMed
Trends in cancer risk among people with AIDS in the United States 1980–2002
TLDR
Dramatic declines in KS and NHL were temporally related to improving therapies, especially introduction of HAART, but those with AIDS remain at marked risk of cancer.
View on Wolters Kluwer
Cancer risk in people infected with human immunodeficiency virus in the United States
TLDR
It is concluded that KS and NHL incidence declined markedly in recent years, likely reflecting HAART‐related improvements in immunity, while incidence of some non‐AIDS‐defining cancers increased, leading to a shift in the spectrum of cancer among HIV‐infected persons.
View on Wiley
Spectrum of AIDS-associated malignant disorders
View on Elsevier
Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology
TLDR
The results indicate that the genetic and biological diversity of HIV-2 is far greater than previously appreciated and suggest that there may be subtype-specific differences in virus biology.
View on ASMUSA
Risk of human papillomavirus-associated cancers among persons with AIDS.
TLDR
Risk of HPV-associated cancers was elevated among persons with AIDS and increased with increasing immunosuppression and the increasing incidence for anal cancer during 1996-2004 indicates that prolonged survival may be associated with increased risk of certain HPV- associated cancers.
View on PubMed
Association of cancer with AIDS-related immunosuppression in adults.
TLDR
Although occurring in overall excess, most non-AIDS-defining cancers do not appear to be influenced by the advancing immunosuppression associated with HIV disease progression.
View on PubMed
Human herpesvirus 8 in Brazilian Amerindians: a hyperendemic population with a new subtype.
TLDR
A new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi's sarcoma has not been reported, and the limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations.
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Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS.
TLDR
It is concluded that HL incidence is lower with severe immunosuppression than with moderate immunOSuppression, and HAART-related improvements in CD4 counts likely explain the increasing HL incidence in PWHAS observed since 1996.
View on PubMed
Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa
TLDR
Nasopharyngeal and oral carcinoma patients from Malaysia, Hong Kong and Sri Lanka who have very high EBV titres show that there is little, if any, cross-reactivity between antibodies to these two gamma viruses, suggesting that human herpes virus-8 (HHV-8) may be either a recently introduced virus or one that has extremely low infectivity.
View on Nature
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