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  • M. Ziche, L. Morbidelli, +4 authors R. Bicknell
  • Medicine
  • The Journal of clinical investigation
  • 1997 (First Publication: 1 June 1997)
  • Systemic administration of the nitric oxide (NO) synthase inhibitor Nomega-nitro--arginine methyl ester (L-NAME) to rabbits bearing a corneal implant blocked vascular endothelial growth factorExpand
  • L. Huminiecki, M. Gorn, S. Suchting, R. Poulsom, R. Bicknell
  • Biology, Medicine
  • Genomics
  • 2002 (First Publication: 1 April 2002)
  • We have used bioinformatic data mining to identify a novel, endothelial-specific gene encoding a protein with homology to the axon guidance protein roundabout (ROBO1). The new gene has been calledExpand
  • M. Relf, S. Lejeune, +7 authors A. Harris
  • Biology, Medicine
  • Cancer research
  • 1997 (First Publication: 1 March 1997)
  • Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined. Multiple angiogenic polypeptides are known, and we haveExpand
  • Helen Sheldon, Maud André, +7 authors Roy Bicknell
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 2009 (First Publication: 1 February 2009)
  • This study aimed to further elucidate the function of Roundabout proteins in endothelium. We show that both Robo1 and Robo4 are present in human umbilical vein endothelial cells (HUVECs) and haveExpand
  • C. Mailhos, U. Modlich, J. Lewis, A. Harris, R. Bicknell, D. Ish-Horowicz
  • Biology, Medicine
  • Differentiation; research in biological diversity
  • 2001 (First Publication: 31 December 2001)
  • Delta-Notch signalling regulates cell-fate choices in a variety of tissues during development. We report the expression of Delta4 (D14) in arterial endothelium during mouse embryogenesis and in theExpand
  • D. Neri, R. Bicknell
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2005 (First Publication: 1 June 2005)
  • It is now accepted that the growth of solid tumours is dependent on their capacity to acquire a blood supply, and much effort has been directed towards the development of agents (known asExpand