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Use of Marfey's reagent and analogs for chiral amino acid analysis: assessment and applications to natural products and biological systems.
The present paper describes an updated knowledge and status on Marfey's reagent (MR), 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (FDNP-L-Ala-NH(2)). The reagent is used for pre-column… Expand
Resolution of enantiomers of amino acids by HPLC.
Application of HPLC as a prime tool in the area of enantiomeric resolution has opened doors of success and varied interest. Use of chiral reagents either indirectly (as derivatization reagent) or… Expand
Indirect resolution of enantiomers of penicillamine by TLC and HPLC using Marfey's reagent and its variants.
TLC and HPLC methods were developed for indirect chiral separation of penicillamine (3,3-dimethylcysteine) enantiomers after derivatization with Marfey's reagent (FDNP-Ala-NH(2)) and two of its… Expand
Direct enantiomeric resolution of (+/-)-atenolol, (+/-)-metoprolol, and (+/-)-propranolol by impregnated TLC using L-aspartic acid as chiral selector.
Resolution of three commonly used beta-blockers, (+/-)-atenolol, (+/-)-metoprolol and (+/-)-propranolol, into their enantiomers has been achieved using normal-phase TLC on silica gel plates… Expand
Direct resolution of enantiomers by impregnated TLC.
Direct resolution of enantiomers has acquired greater analytical importance. Of various chromatographic techniques, TLC continues to enjoy considerable reputation for the purpose. The present paper… Expand
Analysis of multicomponent mixture and simultaneous enantioresolution of proteinogenic and non-proteinogenic amino acids by reversed-phase high-performance liquid chromatography using chiral variants…
Four chiral derivatizing reagents (CDR 1–4), namely, FDNP-l-Ala, FDNP-l-Val, FDNP-l-Phe, and FDNP-l-Leu, were synthesized using microwave (MW) irradiation by substituting one of the fluorine atoms in… Expand
Synthesis of succinimidyl-(S)-naproxen ester and its application for indirect enantioresolution of penicillamine by reversed-phase high-performance liquid chromatography.
Synthesis of N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate was carried out by the reaction of (S)-naproxen with N-hydroxysuccinimide in the presence of dicyclohexyl carbodiimide. It was… Expand
Synthesis and Application of New Chiral Variants of Marfey's Reagent for Liquid Chromatographic Separation of the Enantiomers of α-Amino Acids
Summary Two new structural variants of Marfey's reagent (1-fluoro-2,4-dinitrophenyl-5-l-alaninamide, FDNP-l-Ala-NH2) were synthesized by nucleophilic substitution of one fluorine atom in… Expand
Separation of amino acids, their derivatives and enantiomers by impregnated TLC.
The present state of TLC with respect to separation of amino acids, their different derivatives and their enantiomers by the technique of impregnation is discussed. The main approaches to… Expand