Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice.
- J. Bezault, R. Bhimani, J. Wiprovnick, P. Furmanski
- Biology, ChemistryCancer Research
- 1 May 1994
A novel activity in the multifunctional iron-binding glycoprotein, lactoferrin, is demonstrated and a potentially important role for this molecule in the primary defense against tumorigenesis is suggested.
Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester.
- K. Frenkel, H. Wei, D. Grunberger
- Biology, ChemistryCancer Research
- 15 March 1993
Findings point to CAPE as being a potent chemopreventive agent, which may be useful in combating diseases with strong inflammatory and/or oxidative stress components, i.e., various types of cancer and possibly cataract development.
Inhibition of oxidative stress in HeLa cells by chemopreventive agents.
- R. Bhimani, W. Troll, D. Grunberger, K. Frenkel
- BiologyCancer Research
- 1 October 1993
The results point to 5 compounds as being potential chemopreventive agents, which at very low doses decrease the tumor promoter-mediated oxidative processes, and TAM appears to be the most and Sarp A the least effective.
Influence of lactoferrin feeding and injection against systemic staphylococcal infections in mice
- R. Bhimani, Y. Vendrov, P. Furmanski
- Biology, MedicineJournal of Applied Microbiology
- 1 January 1999
A potential for the use of Lfs as natural antibacterial proteins for preventing bacterial infections is suggested and human and bovine Lfs with different degrees of iron saturation were found to be equipotent.
Mechanism of mutagenicity by 5-hydroperoxymethyl-2'-deoxyuridine, an intermediate product of ionizing radiation, in bacteria. HPMdU bacterial mutagenicity and oxidation of DNA bases.
- U. Patel, R. Bhimani, K. Frenkel
- Chemistry, BiologyMutation research
- 1 October 1992
Human promyelocytic leukemia cells (HL-60): a new model to study the effects of chemopreventive agents on H2O2 production.
- R. Bhimani, Z. Zhong, E. Schleifer, W. Troll, K. Frenkel
- Biology, MedicineCancer Detection and Prevention
- 1995
It is suggested that HL-60 cells can become a useful in vitro system to screen rapidly for chemopreventive agents and to study their properties.
Isolation and Characterization of the Bacteriophages of Lactic Streptococci
- R. Bhimani, Y. M. Freitas
- Biology
- 1 May 1991
Four virulent phages of lactic streptococci were isolated from 245 samples of butter, buttermilk, curd, cheese, cheese whey, raw milk, and Srikhand, and phage FRC4 isolate was specific for Streptococcus lactis ssp.
Functional Significance of the Binding of Lactoferrin to DNA
- P. Furmanski, Jianglin He, L. Ying, J. Bezault, R. Bhimani, K. Ho
- Biology
- 1997
The results offer a potential new insight into the functions of Lf and provide the first example of a novel class of secreted molecules that may activate gene expression in target cells by direct binding to DNA.
Growth Characteristics of Lactococcal Phages Isolated from the Dairy Sources in India
- R. Bhimani, Y. M. Freitas
- Biology
- 1 November 1993
Lactococcal hosts challenged with homologous phages showed greatly decreased culture turbidity and lowered acid production and lower acid production in response to adsorption and phagemediated lysis of host cells.