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RNA Interference: Biology, Mechanism, and Applications
- N. Agrawal, P. V. Dasaradhi, A. Mohmmed, P. Malhotra, R. Bhatnagar, S. Mukherjee
- BiologyMicrobiology and Molecular Biology Reviews
- 1 December 2003
Because of its exquisite specificity and efficiency, RNAi is being considered as an important tool not only for functional genomics, but also for gene-specific therapeutic activities that target the mRNAs of disease-related genes.
Bacterial diversity analysis of larvae and adult midgut microflora using culture-dependent and culture-independent methods in lab-reared and field-collected Anopheles stephensi-an Asian malarial…
This is the first attempt to study the midgut microbiota of Anopheles stephensi from lab-reared and field-collected adult and larvae using "culture-dependent and independent methods", and several of the bacteria identified are related to the known symbionts in other insects.
Silencing of Midgut Aminopeptidase N of Spodoptera litura by Double-stranded RNA Establishes Its Role asBacillus thuringiensis Toxin Receptor*
- R. Rajagopal, S. Sivakumar, N. Agrawal, P. Malhotra, R. Bhatnagar
- BiologyThe Journal of Biological Chemistry
- 6 December 2002
Administration of slapn double-stranded RNA to S. litura larvae reduces its expression and this results directly implicate larval midgut aminopeptidase N as receptor for Bacillus thuringiensis insecticidal proteins.
High-frequency somatic embryo production and maturation into normal plants in cotton (Gossypium hirsutum) through metabolic stress
In this procedure, about 33% of globular embryos not only developed into the cotyledonary stage but rooted simultaneously, eliminating a separate rooting step, and significant improvement in embryogenesis was achieved.
Toxicity Analysis of N- and C-Terminus-Deleted Vegetative Insecticidal Protein from Bacillus thuringiensis
- A. Selvapandiyan, N. Arora, R. Bhatnagar
- BiologyApplied and Environmental Microbiology
- 1 December 2001
Analysis of insecticidal activity with N- and C-terminus deletion mutants suggests a differential mode of action of VIP against different pests.
Knockdown of Aminopeptidase-N from Helicoverpa armigera Larvae and in Transfected Sf21 Cells by RNA Interference Reveals Its Functional Interaction with Bacillus thuringiensis Insecticidal Protein…
- S. Sivakumar, R. Rajagopal, G. Venkatesh, A. Srivastava, R. Bhatnagar
- BiologyJournal of Biological Chemistry
- 9 March 2007
Aminopeptidase-N (APN) and cadherin proteins located at the midgut epithelium of Helicoverpa armigera have been implicated as receptors for the Cry1A subfamily of insecticidal proteins of Bacillus…
Genomic adaptation to polyphagy and insecticides in a major East Asian noctuid pest
The gene families encoding receptors for bitter or toxic substances and detoxification enzymes, such as cytochrome P450, carboxylesterase and glutathione-S-transferase were massively expanded in this polyphagous species, enabling its extraordinary ability to detect and detoxify many plant secondary compounds.
Recombinantly expressed isoenzymic aminopeptidases from Helicoverpa armigera (American cotton bollworm) midgut display differential interaction with closely related Bacillus thuringiensis…
- R. Rajagopal, N. Agrawal, A. Selvapandiyan, S. Sivakumar, Suhail Ahmad, R. Bhatnagar
- BiologyThe Biochemical journal
- 15 March 2003
This is the first report demonstrating differential Cry-toxin-binding abilities of two different aminopeptidases from a susceptible insect.
A constitutively expressed 36 kDa exochitinase from Bacillus thuringiensis HD-1.
Role of RNA Interference (RNAi) in Dengue Virus Replication and Identification of NS4B as an RNAi Suppressor
The results suggest the involvement of miRNA/RNAi pathways in dengue virus establishment and that d Dengue virus NS4B protein plays an important role in the modulation of the host RNAi/miRNA pathway to favor dengued virus replication.