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Stochastic systems
Research in Stochastic Systems focuses on using stochastic modeling and probabilistic analysis to capture the uncertainty in real-world systems, and combining with optimization and optimal controlExpand
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Single-domain/bound calcium hypothesis of transmitter release and facilitation.
1. We describe a model of transmitter release that is based on the finding that release can be gated during the opening of individual Ca2+ channels, suggesting that the release site can be activatedExpand
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Ion channels and signaling in the pituitary gland.
Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium, calcium, potassium, and chloride channels and fire action potentials spontaneously, accompanied by a rise inExpand
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Topological and phenomenological classification of bursting oscillations.
We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of Rinzel (inExpand
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Topological and phenomenological classification of bursting oscillations
We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of RinzelExpand
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Calcium and glycolysis mediate multiple bursting modes in pancreatic islets.
Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period of 10-60 s. InExpand
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Intra- and inter-islet synchronization of metabolically driven insulin secretion.
Insulin secretion from pancreatic beta-cells is pulsatile with a period of 5-10 min and is believed to be responsible for plasma insulin oscillations with similar frequency. To observe an overallExpand
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Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release.
Although single-channel Ca2+ microdomains are capable of gating neurotransmitter release in some instances, it is likely that in many cases the microdomains from several open channels overlap toExpand
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A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.
S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated currentExpand
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Fast-Activating Voltage- and Calcium-Dependent Potassium (BK) Conductance Promotes Bursting in Pituitary Cells: A Dynamic Clamp Study
The electrical activity pattern of endocrine pituitary cells regulates their basal secretion level. Rat somatotrophs and lactotrophs exhibit spontaneous bursting and have high basal levels of hormoneExpand
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