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- R. Bertram
Research in Stochastic Systems focuses on using stochastic modeling and probabilistic analysis to capture the uncertainty in real-world systems, and combining with optimization and optimal control… Expand
Single-domain/bound calcium hypothesis of transmitter release and facilitation.
1. We describe a model of transmitter release that is based on the finding that release can be gated during the opening of individual Ca2+ channels, suggesting that the release site can be activated… Expand
Ion channels and signaling in the pituitary gland.
Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium, calcium, potassium, and chloride channels and fire action potentials spontaneously, accompanied by a rise in… Expand
Topological and phenomenological classification of bursting oscillations.
- R. Bertram, M. Butte, T. Kiemel, A. Sherman
- Mathematics, Medicine
- Bulletin of mathematical biology
We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of Rinzel (in… Expand
Topological and phenomenological classification of bursting oscillations
We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of Rinzel… Expand
Calcium and glycolysis mediate multiple bursting modes in pancreatic islets.
- R. Bertram, L. Satin, Min Zhang, P. Smolen, A. Sherman
- Biology, Medicine
- Biophysical journal
- 1 November 2004
Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory glucose levels. These bursts often have a regular repeating pattern, with a period of 10-60 s. In… Expand
Intra- and inter-islet synchronization of metabolically driven insulin secretion.
Insulin secretion from pancreatic beta-cells is pulsatile with a period of 5-10 min and is believed to be responsible for plasma insulin oscillations with similar frequency. To observe an overall… Expand
Modeling study of the effects of overlapping Ca2+ microdomains on neurotransmitter release.
Although single-channel Ca2+ microdomains are capable of gating neurotransmitter release in some instances, it is likely that in many cases the microdomains from several open channels overlap to… Expand
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.
S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current… Expand
Fast-Activating Voltage- and Calcium-Dependent Potassium (BK) Conductance Promotes Bursting in Pituitary Cells: A Dynamic Clamp Study
- J. Tabak, M. Tomaiuolo, A. González-Iglesias, L. Milescu, R. Bertram
- Chemistry, Medicine
- The Journal of Neuroscience
- 16 November 2011
The electrical activity pattern of endocrine pituitary cells regulates their basal secretion level. Rat somatotrophs and lactotrophs exhibit spontaneous bursting and have high basal levels of hormone… Expand