• Publications
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Transfer function analysis of the circulation: unique insights into cardiovascular regulation.
We have demonstrated previously that transfer function analysis can be used to precisely characterize the respiratory sinus arrhythmia (RSA) in normal humans. To further investigate the role of theExpand
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Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy.
BACKGROUND Dilated cardiomyopathy (DCM) is associated with a high incidence of malignant ventricular arrhythmias and sudden death. Abnormalities in repolarization of ventricular myocardium have beenExpand
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Transfer function analysis of autonomic regulation. I. Canine atrial rate response.
We present a useful technique for analyzing the various functional components that comprise the cardiovascular control network. Our approach entails the imposition of a signal with broad frequencyExpand
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An Efficient Algorithm for Spectral Analysis of Heart Rate Variability
We present a simple efficient algorithm for the derivation of a heart rate signal from the electrocardiogram. We demonstrate that the amplitude spectrum of this heart rate signal more closely matchesExpand
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Pulmonary Vein Anatomy in Patients Undergoing Catheter Ablation of Atrial Fibrillation: Lessons Learned by Use of Magnetic Resonance Imaging
Background—This study sought to define the technique and results of magnetic resonance imaging (MRI) of pulmonary vein (PV) anatomy before and after catheter ablation of atrial fibrillation (AF).Expand
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Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
The KvLQT1 gene encodes a voltage-gated potassium channel. Mutations in KvLQT1 underlie the dominantly transmitted Ward-Romano long QT syndrome, which causes cardiac arrhythmia, and the recessivelyExpand
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Transfer function analysis of autonomic regulation. II. Respiratory sinus arrhythmia.
An efficient new technique was developed to investigate heart rate control at all physiologically relevant frequencies by using respiratory activity as a frequency probe of the autonomic nervousExpand
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Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis.
Neurohumoral modulation of cardiovascular function is an important component of the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis of heart rate (HR)Expand
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Beat to beat variability in cardiovascular variables: noise or music?
Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations haveExpand
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Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Nonischemic Cardiomyopathy
Background— Patients with left ventricular dysfunction have an elevated risk of sudden cardiac death. However, the substrate for ventricular arrhythmia in patients with nonischemic cardiomyopathyExpand
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