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The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains
Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation between diploid a and α strains. The product of mating is a tetraploid a/α cell that must undergo aExpand
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The ‘obligate diploid’ Candida albicans forms mating-competent haploids
Candida albicans, the most prevalent human fungal pathogen, is considered to be an obligate diploid that carries recessive lethal mutations throughout the genome. Here we demonstrate that C. albicansExpand
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Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans
Candida albicans is the most common fungal pathogen in humans, causing both debilitating mucosal infections and potentially life-threatening systemic infections. Until recently, C. albicans wasExpand
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Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm
Many ascomycete yeast species from the Candida genus are widely distributed in nature and act as common saprophytic constituents of the normal human microflora. However, some of these fungal speciesExpand
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Stress-induced phenotypic switching in Candida albicans.
Candida albicans is both a common commensal and an opportunistic pathogen, being a prevalent cause of mucosal and systemic infections in humans. Phenotypic switching between white and opaque forms isExpand
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Genetic Control of Conventional and Pheromone-Stimulated Biofilm Formation in Candida albicans
Candida albicans can stochastically switch between two phenotypes, white and opaque. Opaque cells are the sexually competent form of C. albicans and therefore undergo efficient polarized growth andExpand
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Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis
Sexual reproduction can promote genetic diversity in eukaryotes, and yet many pathogenic fungi have been labeled as obligate asexual species. It is becoming increasingly clear, however, that crypticExpand
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Resolution of holliday junctions by RuvC resolvase: Cleavage specificity and DNA distortion
E. coli RuvC protein resolves Holliday junctions during genetic recombination and postreplication repair. Using small synthetic junctions, we show that junction recognition is structure-specific andExpand
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Structure of a multisubunit complex that promotes DNA branch migration
THE RuvA and RuvB proteins of Escherichia coli, which are induced in response to DNA damage, are important in the formation of heteroduplex DNA during genetic recombination and relatedExpand
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Genetic recombination in E. coli: RuvC protein cleaves Holliday junctions at resolution hotspots in vitro
The E. coli RuvC protein resolves Holliday junctions during genetic recombination and postreplication repair. Using recombination intermediates made by RecA protein, we have identified specificExpand
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