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The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains
- A. Forche, K. Alby, D. Schaefer, A. Johnson, J. Berman, R. Bennett
- Biology, Medicine
- PLoS biology
- 1 May 2008
Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation between diploid a and α strains. The product of mating is a tetraploid a/α cell that must undergo a… Expand
The ‘obligate diploid’ Candida albicans forms mating-competent haploids
- M. Hickman, G. Zeng, +8 authors J. Berman
- Biology, Medicine
- Nature
- 30 January 2013
Candida albicans, the most prevalent human fungal pathogen, is considered to be an obligate diploid that carries recessive lethal mutations throughout the genome. Here we demonstrate that C. albicans… Expand
Homothallic and heterothallic mating in the opportunistic pathogen Candida albicans
- K. Alby, Dana Schaefer, R. Bennett
- Biology, Medicine
- Nature
- 13 August 2009
Candida albicans is the most common fungal pathogen in humans, causing both debilitating mucosal infections and potentially life-threatening systemic infections. Until recently, C. albicans was… Expand
Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm
- N. Papon, V. Courdavault, M. Clastre, R. Bennett
- Biology, Medicine
- PLoS pathogens
- 1 September 2013
Many ascomycete yeast species from the Candida genus are widely distributed in nature and act as common saprophytic constituents of the normal human microflora. However, some of these fungal species… Expand
Stress-induced phenotypic switching in Candida albicans.
- K. Alby, R. Bennett
- Biology, Medicine
- Molecular biology of the cell
- 15 July 2009
Candida albicans is both a common commensal and an opportunistic pathogen, being a prevalent cause of mucosal and systemic infections in humans. Phenotypic switching between white and opaque forms is… Expand
Genetic Control of Conventional and Pheromone-Stimulated Biofilm Formation in Candida albicans
- Ching-Hsuan Lin, Shail Kabrawala, E. Fox, C. J. Nobile, A. Johnson, R. Bennett
- Biology, Medicine
- PLoS pathogens
- 1 April 2013
Candida albicans can stochastically switch between two phenotypes, white and opaque. Opaque cells are the sexually competent form of C. albicans and therefore undergo efficient polarized growth and… Expand
Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis
- A. M. Porman, K. Alby, Matthew P. Hirakawa, R. Bennett
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 8 December 2011
Sexual reproduction can promote genetic diversity in eukaryotes, and yet many pathogenic fungi have been labeled as obligate asexual species. It is becoming increasingly clear, however, that cryptic… Expand
Resolution of holliday junctions by RuvC resolvase: Cleavage specificity and DNA distortion
- R. Bennett, H. J. Dunderdale, S. West
- Biology, Medicine
- Cell
- 24 September 1993
E. coli RuvC protein resolves Holliday junctions during genetic recombination and postreplication repair. Using small synthetic junctions, we show that junction recognition is structure-specific and… Expand
Structure of a multisubunit complex that promotes DNA branch migration
- C. A. Parsons, A. Stasiak, R. Bennett, S. West
- Biology, Medicine
- Nature
- 23 March 1995
THE RuvA and RuvB proteins of Escherichia coli, which are induced in response to DNA damage, are important in the formation of heteroduplex DNA during genetic recombination and related… Expand
Genetic recombination in E. coli: RuvC protein cleaves Holliday junctions at resolution hotspots in vitro
- R. Shah, R. Bennett, S. West
- Biology, Medicine
- Cell
- 2 December 1994
The E. coli RuvC protein resolves Holliday junctions during genetic recombination and postreplication repair. Using recombination intermediates made by RecA protein, we have identified specific… Expand